Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0Y8C6 | IPO5 | Importin-5 (Importin subunit beta-3) (Karyopherin … | Homo sapiens (Human) | 1099 aa |
Protein Details: H0Y8C6 (IPO5)
Protein Information
| Accession | H0Y8C6 |
|---|---|
| Protein Names | Importin-5 (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) |
| Gene Symbol | IPO5 |
| Organism | Homo sapiens (Human) |
| Length | 1099 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.862
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.862
25/46 (54.3%)
4
PC3 cells
Specificity: 0.138
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501XFRPLLPRRL11APVTSPPPLA21PTCGRSRRAP31VQETYENIPG41QSKITFLLQA
51-10051IRNTTAAEEA61RQMAAVLLRR71LLSSAFDEVY81PALPSDVQTA91IKSELLMIIQ
101-150101METQSSMRKK111VCDIAAELAR121NLIDEDGNNQ131WPEGLKFLFD141SVSSQNVGLR
151-200151EAALHIFWNF161PGIFGNQQQH171YLDVIKRMLV181QCMQDQEHPS191IRTLSARATA
201-250201AFILANEHNV211ALFKHFADLL221PGFLQAVNDS231CYQNDDSVLK241SLVEIADTVP
251-300251KYLRPHLEAT261LQLSLKLCGD271TSLNNMQRQL281ALEVIVTLSE291TAAAMLRKHT
301-350301NIVAQTIPQM311LAMMVDLEED321EDWANADELE331DDDFDSNAVA341GESALDRMAC
351-400351GLGGKLVLPM361IKEHIMQMLQ371NPDWKYRHAG381LMALSAIGEG391CHQQMEGILN
401-450401EIVNFVLLFL411QDPHPRVRYA421ACNAVGQMAT431DFAPGFQKKF441HEKVIAALLQ
451-500451TMEDQGNQRV461QAHAAAALIN471FTEDCPKSLL481IPYLDNLVKH491LHSIMVLKLQ
501-550501ELIQKGTKLV511LEQVVTSIAS521VADTAEEKFV531PYYDLFMPSL541KHIVENAVQK
551-600551ELRLLRGKTI561ECISLIGLAV571GKEKFMQDAS581DVMQLLLKTQ591TDFNDMEDDD
601-650601PQISYMISAW611ARMCKILGKE621FQQYLPVVMG631PLMKTASIKP641EVALLDTQDM
651-700651ENMSDDDGWE661FVNLGDQQSF671GIKTAGLEEK681STACQMLVCY691AKELKEGFVE
701-750701YTEQVVKLMV711PLLKFYFHDG721VRVAAAESMP731LLLECARVRG741PEYLTQMWHF
751-800751MCDALIKAIG761TEPDSDVLSE771IMHSFAKCIE781VMGDGCLNNE791HFEELGGILK
801-850801AKLEEHFKNQ811ELRQVKRQDE821DYDEQVEESL831QDEDDNDVYI841LTKVSDILHS
851-900851IFSSYKEKVL861PWFEQLLPLI871VNLICPHRPW881PDRQWGLCIF891DDVIEHCSPA
901-950901SFKYAEYFLR911PMLQYVCDNS921PEVRQAAAYG931LGVMAQYGGD941NYRPFCTEAL
951-1000951PLLVRVIQSA961DSKTKENVNA971TENCISAVGK981IMKFKPDCVN991VEEVLPHWLS
1001-10501001WLPLHEDKEE1011AVQTFNYLCD1021LIESNHPIVL1031GPNNTNLPKI1041FSIIAEGEMH
1051-10991051EAIKHEDPCA1061KRLANVVRQV1071QTSGGLWTEC1081IAQLSPEQQA1091AIQELLNSA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 23 | Prediction (Medium) | - | - |
| 112 | Prediction (High) | - | - |
| 182 | Prediction (Medium) | - | - |
| 268 | Prediction (High) | - | - |
| 350 | Prediction (High) | - | - |
| 391 | Prediction (Medium) | - | - |
| 475 | Prediction (Low) | - | - |
| 562 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 614 | Prediction (Medium) | - | - |
| 689 | Prediction (Medium) | - | - |
| 735 | Prediction (High) | - | - |
| 875 | Prediction (Medium) | - | - |
| 917 | Prediction (Low) | - | - |
| 946 | Prediction (Medium) | - | - |
| 974 | Prediction (Medium) | - | - |
| 988 | Prediction (Medium) | - | - |
| 1059 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 169 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 389 | C → C | 0.002288 | SNP | Silent | STAD |
| 438 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 678 | K → delinsNKCI | 0.001764 | INS | In Frame Ins | LUAD |
| 737 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 737 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 850 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 878 | W → C | 0.002545 | SNP | Missense Mutation | GBM |
| 941 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1060 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 1078 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |