Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YC03 | TOP1MT | DNA topoisomerase I mitochondrial | Homo sapiens (Human) | 123 aa |
Protein Details: H0YC03 (TOP1MT)
Protein Information
| Accession | H0YC03 |
|---|---|
| Protein Names | DNA topoisomerase I mitochondrial |
| Gene Symbol | TOP1MT |
| Organism | Homo sapiens (Human) |
| Length | 123 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLRLRAALTL11LGEVPRRPAS21RGVPGSRRTQ31KGSGARWEKE41KHEDGVKWRQ
51-10051LEHKGPYFAP61PYEPLPDGVR71FFYEGRPVRL81SVAAEEVATF91YGRMLDHEYT
101-123101TKEVFRKNFF111NDWRKVLCQT121HML
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 118 | SWISSPALM DBPTM CYSMODDB | Eukaryotic DNA topoisomerase I DNA binding fragment | - | - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 200 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 200 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 294 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 370 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 443 | R → C | 0.002506 | SNP | Missense Mutation | COAD |