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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H0YC03 TOP1MT DNA topoisomerase I mitochondrial Homo sapiens (Human) 123 aa

Protein Details: H0YC03 (TOP1MT)

Protein Information
Accession H0YC03
Protein Names DNA topoisomerase I mitochondrial
Gene Symbol TOP1MT
Organism Homo sapiens (Human)
Length 123 aa
Isoforms No isoforms
Related PMIDs 31251020
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 1.000
36/46 (78.3%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLRLRAALTL11LGEVPRRPAS21RGVPGSRRTQ31KGSGARWEKE41KHEDGVKWRQ
51-10051LEHKGPYFAP61PYEPLPDGVR71FFYEGRPVRL81SVAAEEVATF91YGRMLDHEYT
101-123101TKEVFRKNFF111NDWRKVLCQT121HML
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
118 CYSMODDB SWISSPALM DBPTM Prediction (High) Eukaryotic DNA topoisomerase I DNA binding fragment -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
200 R → C 0.002288 SNP Missense Mutation STAD
200 R → C 0.002506 SNP Missense Mutation COAD
294 R → C 0.001887 SNP Missense Mutation UCEC
370 C → Y 0.001887 SNP Missense Mutation UCEC
443 R → C 0.002506 SNP Missense Mutation COAD