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UniProt ID Gene Symbol Protein Name Organism Length Action
H0YC48 HACE1 HECT domain and ankyrin repeat … Homo sapiens (Human) 175 aa

Protein Details: H0YC48 (HACE1)

Protein Information
AccessionH0YC48
Protein NamesHECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Gene SymbolHACE1
OrganismHomo sapiens (Human)
Length175 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501XQDAASIPPF11EPPGPGSYEN21LSTGTRESKP31DALAGRQEAS41ADCQDVISMT
51-10051ANRLSAVIQA61FYMCCSCQMP71PGMTSPRFIE81FVCKHDEVLK91CFVNRNPKII
101-150101FDHFHFLLEC111PELMSRFMHI121IKAQPFKDRC131EWFYEHLHSG141QPDSDMVHRP
151-175151VNENDILLVH161RGVAVKLCQK171QIVQS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
43 - - -
GPS-Palm: 0.71
Deep-Palm: 0.90
64 - - -
Deep-Palm: 0.07
65 - - -
Deep-Palm: 0.10
67 - - -
Deep-Palm: 0.08
83 - - -
Deep-Palm: 0.32
91 - - -
GPS-Palm: 0.70
Deep-Palm: 0.05
110 - - -
Deep-Palm: 0.22
130 - - -
Deep-Palm: 0.06
168 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.92
Deep-Palm: 0.10
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
328 C → Y 0.001887 SNP Missense Mutation UCEC
416 Y → C 0.002033 SNP Missense Mutation LUSC
481 C → S 0.002033 SNP Missense Mutation LUSC
527 R → C 0.002141 SNP Missense Mutation SKCM
906 Y → C 0.002033 SNP Missense Mutation LUSC