Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YDD4 | DLAT | Acetyltransferase component of pyruvate dehydrogenase … | Homo sapiens (Human) | 520 aa |
Protein Details: H0YDD4 (DLAT)
Protein Information
| Accession | H0YDD4 |
|---|---|
| Protein Names | Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) |
| Gene Symbol | DLAT |
| Organism | Homo sapiens (Human) |
| Length | 520 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32651440 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWRVCARRAQ11NVAPWAGLEA21RWTALQEVPG31TPRVTSRSGP41APARRNSVTT
51-10051GYGGVRALCG61WTPSSGATPR71NRLLLQLLGS81PGRRYYSLPP91HQKVPLPSLS
101-150101PTMQAGTIAR111WEKKEGDKIN121EGDLLAEIET131DKATIGFEVQ141EEGYLAKILV
151-200151PEGTRDVPLG161TPLCIIVEKE171ADISAFADYR181PTEVTDLKPQ191VPPPTPPPVA
201-250201AVPPTPQPLA211PTPSAPCPAT221PAGPKGRVFV231SPLAKKLAVE241KGIDLTQVKG
251-300251TGPDGRITKK261DIDSFVPSKV271APAPAAVVPP281TGPGMAPVPT291GVFTDIPISN
301-350301IRRVIAQRLM311QSKQTIPHYY321LSIDVNMGEV331LLVRKELNKI341LEGRSKISVN
351-400351DFIIKASALA361CLKVPEANSS371WMDTVIRQNH381VVDVSVAVST391PAGLITPIVF
401-450401NAHIKGVETI411ANDVVSLATK421AREGKLQPHE431FQGGTFTISN441LGMFGIKNFS
451-500451AIINPPQACI461LAIGASEDKL471VPADNEKGFD481VASMMSVTLS491CDHRVVDGAV
501-520501GAQWLAEFRK511YLEKPITMLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.05
|
|
| 59 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
|
| 164 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.97
|
|
| 217 | - | - | - |
Deep-Palm: 0.95
|
|
| 361 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.91
|
|
| 459 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.79
Deep-Palm: 0.95
|
|
| 491 | - | - | - |
Deep-Palm: 0.83
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
LNCaP
Specificity: 0.286
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.286
4/4 (100.0%)
1
Jurkat T cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.286
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.071
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 144 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 488 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |