Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YDL9 | CD81 | Tetraspanin | Homo sapiens (Human) | 221 aa |
Protein Details: H0YDL9 (CD81)
Protein Information
| Accession | H0YDL9 |
|---|---|
| Protein Names | Tetraspanin |
| Gene Symbol | CD81 |
| Organism | Homo sapiens (Human) |
| Length | 221 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XQRGFPQLAG11GVILGVALWL21RHDPQTTNLL31YLELGDKPAP41NTFYVGIYIL
51-10051IAVGAVMMFV61GFLGCYGAIQ71ESQCLLGTFF81TCLVILFACE91VAAGIWGFVN
101-150101KDQIAKDVKQ111FYDQALQQAV121VDDDANNAKA131VVKTFHETLD141CCGSSTLTAL
151-200151TTSVLKNNLC161PSGSNIISNL171FKEDCHQKID181DLFSGKLYLI191GIAAIVVAVI
201-221201MVSGRGRRAC211SLGCPFRGAL221C
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 65 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.95
|
|
| 74 | - | - | - |
Deep-Palm: 0.89
|
|
| 82 | - | - | - |
Deep-Palm: 0.94
|
|
| 89 | - | - | - |
Deep-Palm: 0.38
|
|
| 141 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.82
Deep-Palm: 0.95
|
| 142 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.90
Deep-Palm: 0.92
|
| 160 | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.75
Deep-Palm: 0.88
|
|
| 175 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.65
Deep-Palm: 0.36
|
|
| 210 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.37
|
|
| 214 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.11
|
|
| 221 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
2
LNCaP cells (Mass)
Specificity: 0.154
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 157 | C → F | 0.003559 | SNP | Missense Mutation | KIRP |
| ? | ? → ? | 0.001887 | SNP | Missense Mutation | UCEC |