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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H0YEF4 ZDHHC5 protein S-acyltransferase (EC 2.3.1.225) Homo sapiens (Human) 300 aa

Protein Details: H0YEF4 (ZDHHC5)

Protein Information
AccessionH0YEF4
Protein Namesprotein S-acyltransferase (EC 2.3.1.225)
Gene SymbolZDHHC5
OrganismHomo sapiens (Human)
Length300 aa
IsoformsNo isoforms
Related PMIDs 29575903 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501RAEEDEDKED11DFRAPLYKTV21EIKGIQVRMK31WCATCRFYRP41PRCSHCSVCD
51-10051NCVEVTGKFR61GGVNPFTNGC71CNNVSRVLCS81SPAPRYLGRP91KKEKTIVIRP
101-150101PFLRPEVSDG111QITVKIMDNG121IQGELRRTKS131KGSLEITESQ141SADAEPPPPP
151-200151KPDLSRYTGL161RTHLGLATNE171DSSLLAKDSP181PTPTMYKYRP191GYSSSSTSAA
201-250201MPHSSSAKLS211RGDSLKEPTS221IAESSRHPSY231RSEPSLEPES241FRSPTFGKSF
251-300251HFDPLSSGSR261SSSLKSAQGT271GFELGQLQSI281RSEGTTSTSY291KSLANQTRNG
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
32 Palmitoyltransferase, DHHC domain ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 DHHC domain profile. - -
GPS-Palm: 0.89
Deep-Palm: 0.28
35 Palmitoyltransferase, DHHC domain ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 DHHC domain profile. - -
GPS-Palm: 0.87
Deep-Palm: 0.15
43 - - -
Deep-Palm: 0.12
46 - - -
Deep-Palm: 0.15
49 - - -
Deep-Palm: 0.16
52 - - -
Deep-Palm: 0.17
70 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
Deep-Palm: 0.64
71 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
Deep-Palm: 0.57
79 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.85
Deep-Palm: 0.55
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
LNCaP
Specificity: 0.250
4/4 (100.0%)
4
PC3
Specificity: 0.250
4/4 (100.0%)
3
cerebral cortex
Specificity: 0.188
3/3 (100.0%)
1
HeLa cell
Specificity: 0.062
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
LNCaP cells (Mass)
Specificity: 0.125
2/4 (50.0%)
2
Cerebral Cortex (Mass)
Specificity: 0.125
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
102 R → C 0.002506 SNP Missense Mutation COAD
102 R → C 0.001887 SNP Missense Mutation UCEC
134 C → C 0.001014 SNP Silent BRCA
140 C → C 0.006993 SNP Silent LAML
215 R → C 0.002506 SNP Missense Mutation COAD
409 S → C 0.001014 SNP Missense Mutation BRCA
538 R → C 0.002288 SNP Missense Mutation STAD
538 R → C 0.002506 SNP Missense Mutation COAD
538 R → C 0.003774 SNP Missense Mutation UCEC
708 G → C 0.001014 SNP Missense Mutation BRCA
236* C → ? 0.001887 SNP Nonsense Mutation UCEC