Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YGV7 | MAN1B1 | alpha-1,2-Mannosidase (EC 3.2.1.-) | Homo sapiens (Human) | 550 aa |
Protein Details: H0YGV7 (MAN1B1)
Protein Information
| Accession | H0YGV7 |
|---|---|
| Protein Names | alpha-1,2-Mannosidase (EC 3.2.1.-) |
| Gene Symbol | MAN1B1 |
| Organism | Homo sapiens (Human) |
| Length | 550 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAACEGRRSG11ALGSSQSDFL21TPPVGGAPWA31VATTVVMYPP41PPPPPHRDFI
51-10051SVTLSFGENY61DNSKSWRRRS71CWRKWKQLSR81LQRNMILFLL91AFLLFCGLLF
101-150101YINLADHWKA111LAFRLEEEQK121MRPEIAGLKP131ANPPVLPAPQ141KADTDPENLP
151-200151EISSQKTQRH161IQRGPPHLQI171RPPSQDLKDG181TQEEATKRQE191APVDPRPEGD
201-250201PQRTVISWRG211AVIEPEQGTE221LPSRRAEVPT231KPPLPPARTQ241GTPVHLNYRQ
251-300251KGVIDVFLHA261WKGYRKFAWG271HDELKPVSRS281FSEWFGLGLT291LIDALDTMWI
301-350301LGLRKEFEEA311RKWVSKKLHF321EKDVDVNLFE331STIRILGGLL341SAYHLSGDSL
351-400351FLRKAEDFGN361RLMPAFRTPS371KIPYSDVNIG381TGVAHPPRWT391SDSTVAEVTS
401-450401IQLEFRELSR411LTGDKKFQEA421VEKVTQHIHG431LSGKKDGLVP441MFINTHSGLF
451-500451THLGVFTLGA461RADSYYEYLL471KQWIQGGKQE481TQLLEDYVEA491IEGVRTHLLR
501-550501HSEPSKLTFV511GELAHGRFSA521KMGRWLWAST531TACPPATWSW541PRSSWRLVTR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.06
|
|
| 71 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.42
|
|
| 96 | - | - | - |
Deep-Palm: 0.79
|
|
| 533 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.68
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
2
HeLa cell
Specificity: 0.400
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 249 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 265 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 281 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 502 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 619 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |