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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H0YJ34 FERMT2 FERM domain containing kindlin 2 Homo sapiens (Human) 640 aa

Protein Details: H0YJ34 (FERMT2)

Protein Information
AccessionH0YJ34
Protein NamesFERM domain containing kindlin 2
Gene SymbolFERMT2
OrganismHomo sapiens (Human)
Length640 aa
IsoformsNo isoforms
Related PMIDs 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501SDHALWWEKK11RTWLLKTHWT21LDKYGIQADA31KLQFTPQHKL41LRLQLPNMKY
51-10051VKVKVNFSDR61VFKAVSDICK71TFNIRHPEEL81SLLKKPRDPT91KKKKKKLDDQ
101-150101SEDEALELEG111PLITPGSGTD121VLYIGPLKGS131IYSSPGLYSK141TMTPTYDAHD
151-200151GSPLSPTSAW161FGDSALSEGN171PGILAVSQPI181TSPEILAKMF191KPQALLDKAK
201-250201INQGWLDSSR211SLMEQDVKEN221EALLLRFKYY231SFFDLNPKYD241AIRINQLYEQ
251-300251AKWAILLEEI261ECTEEEMMMF271AALQYHINKL281SIMTSENHLN291NSDKEVDEVD
301-350301AALSDLEITL311EGGKTSTILG321DITSIPELAD331YIKVFKPKKL341TLKGYKQYWC
351-400351TFKDTSISCY361KSKEESSGTP371AHQMNLRGCE381VTPDVNISGQ391KFNIKLLIPV
401-450401AEGMNEIWLR411CDNEKQYAHW421MAACRLASKG431KTMADSSYNL441EVQNILSFLK
451-500451MQHLNPDPQL461IPEQITTDIT471PECLVSPRYL481KKYKNKQPGY491IRDLITARIL
501-550501EAHQNVAQMS511LIEAKMRFIQ521AWQSLPEFGI531THFIARFQGG541KKEELIGIAY
551-600551NRLIRMDAST561GDAIKTWRFS571NMKQWNVNWE581IKMVTVEFAD591EVRLSFICTE
601-640601VDCKVVHEFI611GGYIFLSTRA621KDQNESLDEE631MFYKLTSGWV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
69 - - -
GPS-Palm: 0.82
Deep-Palm: 0.88
262 - - -
Deep-Palm: 0.23
350 - - -
Deep-Palm: 0.50
359 - - -
Deep-Palm: 0.05
379 SWISSPALM DBPTM CYSMODDB - -
cerebral cortex (36430497)
Deep-Palm: 0.55
411 - - -
Deep-Palm: 0.11
424 - - -
GPS-Palm: 0.89
Deep-Palm: 0.28
473 - - -
GPS-Palm: 0.91
Deep-Palm: 0.85
598 - - -
Deep-Palm: 0.32
603 - - -
Deep-Palm: 0.21
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
PC3
Specificity: 0.400
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.200
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
115 F → C 0.007299 SNP Missense Mutation READ
397 C → C 0.006993 SNP Silent LAML
426 C → Mfs*2 0.002545 INS Frame Shift Ins GBM
439 F → C 0.002506 SNP Missense Mutation COAD
525 R → C 0.002747 SNP Missense Mutation LIHC
558 F → C 0.001887 SNP Missense Mutation UCEC
608 R → C 0.001887 SNP Missense Mutation UCEC
679 W → C 0.001764 SNP Missense Mutation LUAD