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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H0YJ34 FERMT2 FERM domain containing kindlin 2 Homo sapiens (Human) 640 aa

Protein Details: H0YJ34 (FERMT2)

Protein Information
Accession H0YJ34
Protein Names FERM domain containing kindlin 2
Gene Symbol FERMT2
Organism Homo sapiens (Human)
Length 640 aa
Isoforms No isoforms
Related PMIDs 19801377 29575903 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.400
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.400
4/4 (100.0%)
1
DU145 cells
Specificity: 0.100
1/2 (50.0%)
1
HeLa cells
Specificity: 0.100
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501SDHALWWEKK11RTWLLKTHWT21LDKYGIQADA31KLQFTPQHKL41LRLQLPNMKY
51-10051VKVKVNFSDR61VFKAVSDICK71TFNIRHPEEL81SLLKKPRDPT91KKKKKKLDDQ
101-150101SEDEALELEG111PLITPGSGTD121VLYIGPLKGS131IYSSPGLYSK141TMTPTYDAHD
151-200151GSPLSPTSAW161FGDSALSEGN171PGILAVSQPI181TSPEILAKMF191KPQALLDKAK
201-250201INQGWLDSSR211SLMEQDVKEN221EALLLRFKYY231SFFDLNPKYD241AIRINQLYEQ
251-300251AKWAILLEEI261ECTEEEMMMF271AALQYHINKL281SIMTSENHLN291NSDKEVDEVD
301-350301AALSDLEITL311EGGKTSTILG321DITSIPELAD331YIKVFKPKKL341TLKGYKQYWC
351-400351TFKDTSISCY361KSKEESSGTP371AHQMNLRGCE381VTPDVNISGQ391KFNIKLLIPV
401-450401AEGMNEIWLR411CDNEKQYAHW421MAACRLASKG431KTMADSSYNL441EVQNILSFLK
451-500451MQHLNPDPQL461IPEQITTDIT471PECLVSPRYL481KKYKNKQPGY491IRDLITARIL
501-550501EAHQNVAQMS511LIEAKMRFIQ521AWQSLPEFGI531THFIARFQGG541KKEELIGIAY
551-600551NRLIRMDAST561GDAIKTWRFS571NMKQWNVNWE581IKMVTVEFAD591EVRLSFICTE
601-640601VDCKVVHEFI611GGYIFLSTRA621KDQNESLDEE631MFYKLTSGWV
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
69 Prediction (Medium) - -
379 CYSMODDB SWISSPALM DBPTM - -
424 Prediction (Medium) - -
473 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
115 F → C 0.007299 SNP Missense Mutation READ
397 C → C 0.006993 SNP Silent LAML
426 C → Mfs*2 0.002545 INS Frame Shift Ins GBM
439 F → C 0.002506 SNP Missense Mutation COAD
525 R → C 0.002747 SNP Missense Mutation LIHC
558 F → C 0.001887 SNP Missense Mutation UCEC
608 R → C 0.001887 SNP Missense Mutation UCEC
679 W → C 0.001764 SNP Missense Mutation LUAD