Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YL10 | CD276 | CD276 molecule | Homo sapiens (Human) | 199 aa |
Protein Details: H0YL10 (CD276)
Protein Information
| Accession | H0YL10 |
|---|---|
| Protein Names | CD276 molecule |
| Gene Symbol | CD276 |
| Organism | Homo sapiens (Human) |
| Length | 199 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRVRVADEGS11FTCFVSIRDF21GSAAVSLQVA31APYSKPSMTL41EPNKDLRPGD
51-10051TVTITCSSYR61GYPEAEVFWQ71DGQGVPLTGN81VTTSQMANEQ91GLFDVHSVLR
101-150101VVLGANGTYS111CLVRNPVLQQ121DAHGSVTITE131ALWVTVGLSV141CLIALLVALA
151-199151FVCWRKIKQS161CEEENAGAED171QDGEGEGSKT181ALQPLKHSDS191KEDDGQEIA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.72
Deep-Palm: 0.72
|
|
| 56 | SWISSPALM DBPTM CYSMODDB | Immunoglobulin domain | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.76
|
| 111 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.95
|
|
| 141 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.84
|
|
| 153 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 161 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.400
4/4 (100.0%)
4
PC3
Specificity: 0.400
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP cells (Mass)
Specificity: 0.200
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | C → C | 0.002427 | SNP | Silent | BLCA |
| 92 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 92 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 130 | G → C | 0.010870 | SNP | Missense Mutation | ACC |
| 349 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.002288 | SNP | Missense Mutation | STAD |