Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0YMW4 | ANXA2 | Annexin | Homo sapiens (Human) | 367 aa |
Protein Details: H0YMW4 (ANXA2)
Protein Information
| Accession | H0YMW4 |
|---|---|
| Protein Names | Annexin |
| Gene Symbol | ANXA2 |
| Organism | Homo sapiens (Human) |
| Length | 367 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSWPCDSVIN11QDHKTKEKNI21CFQKASFKMS31TVHEILCKLS41LEGDHSTPPS
51-10051AYGSVKAYTN61FDAERDALNI71ETAIKTKGVD81EVTIVNILTN91RSNAQRQDIA
101-150101FAYQRRTKKE111LASALKSALS121GHLETVILGL131LKTPAQYDAS141ELKASMKGLG
151-200151TDEDSLIEII161CSRTNQELQE171INRVYKEMYK181TDLEKDIISD191TSGDFRKLMV
201-250201ALAKGRRAED211GSVIDYELID221QDARDLYDAG231VKRKGTDVPK241WISIMTERSV
251-300251PHLQKVFDRY261KSYSPYDMLE271SIRKEVKGDL281ENAFLNLVQC291IQNKPLYFAD
301-350301RLYDSMKGKG311TRDKVLIRIM321VSRSEVDMLK331IRSEFKRKYG341KSLYYYIQQD
351-367351TKGDYQKALL361YLCGGDD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.01
|
|
| 21 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.29
|
|
| 37 | SWISSPALM DBPTM CYSMODDB | Annexin A2 |
HeLa
(29575903)
| - |
Deep-Palm: 0.89
|
| 161 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.70
Deep-Palm: 0.96
|
|
| 290 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.88
|
|
| 363 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
PC3
Specificity: 0.800
4/4 (100.0%)
1
LNCaP
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 165 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 213 | W → C | 0.005435 | SNP | Missense Mutation | ESCA |