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UniProt ID Gene Symbol Protein Name Organism Length Action
H0YN29 CD276 CD276 molecule Homo sapiens (Human) 170 aa

Protein Details: H0YN29 (CD276)

Protein Information
AccessionH0YN29
Protein NamesCD276 molecule
Gene SymbolCD276
OrganismHomo sapiens (Human)
Length170 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MTLEPNKDLR11PGDTVTITCS21SYRGYPEAEV31FWQDGQGVPL41TGNVTTSQMA
51-10051NEQGLFDVHS61VLRVVLGANG71TYSCLVRNPV81LQQDAHGSVT91ITGQPMTFPP
101-150101EALWVTVGLS111VCLIALLVAL121AFVCWRKIKQ131SCEEENAGAE141DQDGEGEGSK
151-170151TALQPLKHSD161SKEDDGQEIA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
19 SWISSPALM DBPTM CYSMODDB Immunoglobulin-like fold Immunoglobulin-like domain superfamily Immunoglobulin-like beta-sandwich domain - -
GPS-Palm: 0.79
Deep-Palm: 0.76
74 - - -
GPS-Palm: 0.87
Deep-Palm: 0.95
112 - - -
GPS-Palm: 0.67
Deep-Palm: 0.98
124 - - -
GPS-Palm: 0.94
Deep-Palm: 0.98
132 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
-
Deep-Palm: 0.96
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.500
4/4 (100.0%)
4
PC3
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
24 C → C 0.002427 SNP Silent BLCA
92 R → C 0.002506 SNP Missense Mutation COAD
92 R → C 0.003460 SNP Missense Mutation CESC
130 G → C 0.010870 SNP Missense Mutation ACC
349 S → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.002288 SNP Missense Mutation STAD