Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BLW6 | TMEM63B | Transmembrane protein 63B | Homo sapiens (Human) | 761 aa |
Protein Details: H3BLW6 (TMEM63B)
Protein Information
| Accession | H3BLW6 |
|---|---|
| Protein Names | Transmembrane protein 63B |
| Gene Symbol | TMEM63B |
| Organism | Homo sapiens (Human) |
| Length | 761 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XSILRKVAWD11YGRLALVTDA21DSVASAMHGD31SHDRYERLTS41VSSSVDFDQR
51-10051DNGFCSWLTA61IFRIKDDEIR71DKCGGDAVHY81LSFQRHIIGL91LVVVGVLSVG
101-150101IVLPVNFSGD111LLENNAYSFG121RTTIANLKSG131NNLLWLHTSF141AFLYLLLTVY
151-200151SMRRHTSKMR161YKEDDLVKRT171LFINGISKYA181ESEKIKKHFE191EAYPNCTVLE
201-250201ARPCYNVARL211MFLDAERKKA221ERGKLYFTNL231QSKENVPTMI241NPKPCGHLCC
251-300251CVVRGCEQVE261AIEYYTKLEQ271KLKEDYKREK281EKVNEKPLGM291AFVTFHNETI
301-350301TAIILKDFNV311CKCQGCTCRG321EPRPSSCSES331LHISNWTVSY341APDPQNIYWE
351-400351HLSIRGFIWW361LRCLVINVVL371FILLFFLTTP381AIIITTMDKF391NVTKPVEYLN
401-450401NPIITQFFPT411LLLWCFSALL421PTIVYYSAFF431EAHWTRSGEN441RTTMHKCYTF
451-500451LIFMVLLLPS461LGLSSLDLFF471RWLFDKKFLA481EAAIRFECVF491LPDNGAFFVN
501-550501YVIASAFIGN511AMDLLRIPGL521LMYMIRLCLA531RSAAERRNVK541RHQAYEFQFG
551-600551AAYAWMMCVF561TVVMTYSITC571PIIVPFGLMY581MLLKHLVDRY591NLYYAYLPAK
601-650601LDKKIHSGAV611NQVVAAPILC621LFWLLFFSTM631RTGFLAPTSM641FTFVVLVITI
651-700651VICLCHVCFG661HFKYLSAHNY671KIEHTETDTV681DPRSNGRPPT691AAAVPKSAKY
701-750701IAQVLQDSEV711DGDGDGAPGS721SGDEPPSSSS731QDEELLMPPD741ALTDTDFQSC
751-761751EDSLIENEIH761Q
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 55 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.65
Deep-Palm: 0.69
|
| 73 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.68
|
|
| 196 | - | - | - |
Deep-Palm: 0.84
|
|
| 204 | - | - | - |
Deep-Palm: 0.74
|
|
| 245 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.32
|
|
| 249 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.13
|
|
| 250 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.10
|
|
| 251 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.14
|
|
| 256 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.24
|
|
| 311 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.14
|
|
| 313 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.15
|
|
| 316 | - | - | - |
Deep-Palm: 0.25
|
|
| 318 | - | - | - |
Deep-Palm: 0.13
|
|
| 327 | - | - | - |
Deep-Palm: 0.14
|
|
| 363 | - | - | - |
Deep-Palm: 0.22
|
|
| 415 | - | - | - |
Deep-Palm: 0.38
|
|
| 447 | - | - | - |
Deep-Palm: 0.47
|
|
| 488 | - | - | - |
Deep-Palm: 0.65
|
|
| 528 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.96
|
|
| 558 | - | - | - |
Deep-Palm: 0.03
|
|
| 570 | - | - | - |
Deep-Palm: 0.03
|
|
| 620 | - | - | - |
Deep-Palm: 0.66
|
|
| 653 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.05
|
|
| 655 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.04
|
|
| 658 | - | - | - |
Deep-Palm: 0.11
|
|
| 750 | - | - | - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
LNCaP
Specificity: 0.214
3/3 (100.0%)
3
PC3
Specificity: 0.214
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.214
3/3 (100.0%)
1
DU145 cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
Cerebral Cortex (Mass)
Specificity: 0.214
3/4 (75.0%)
1
LNCaP cells (Mass)
Specificity: 0.071
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 108 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 128 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 231 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 303 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 394 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 431 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 433 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 542 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 580 | G → C | 0.002033 | SNP | Missense Mutation | THCA |
| 587 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 651 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 702 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 735 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |