Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BLW6 | TMEM63B | Transmembrane protein 63B | Homo sapiens (Human) | 761 aa |
Protein Details: H3BLW6 (TMEM63B)
Protein Information
| Accession | H3BLW6 |
|---|---|
| Protein Names | Transmembrane protein 63B |
| Gene Symbol | TMEM63B |
| Organism | Homo sapiens (Human) |
| Length | 761 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.778
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
28
LNCaP cells
Specificity: 0.778
28/46 (60.9%)
3
PC3 cells
Specificity: 0.083
3/4 (75.0%)
3
Cerebral cortex
Specificity: 0.083
3/4 (75.0%)
2
DU145 cells
Specificity: 0.056
2/2 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501XSILRKVAWD11YGRLALVTDA21DSVASAMHGD31SHDRYERLTS41VSSSVDFDQR
51-10051DNGFCSWLTA61IFRIKDDEIR71DKCGGDAVHY81LSFQRHIIGL91LVVVGVLSVG
101-150101IVLPVNFSGD111LLENNAYSFG121RTTIANLKSG131NNLLWLHTSF141AFLYLLLTVY
151-200151SMRRHTSKMR161YKEDDLVKRT171LFINGISKYA181ESEKIKKHFE191EAYPNCTVLE
201-250201ARPCYNVARL211MFLDAERKKA221ERGKLYFTNL231QSKENVPTMI241NPKPCGHLCC
251-300251CVVRGCEQVE261AIEYYTKLEQ271KLKEDYKREK281EKVNEKPLGM291AFVTFHNETI
301-350301TAIILKDFNV311CKCQGCTCRG321EPRPSSCSES331LHISNWTVSY341APDPQNIYWE
351-400351HLSIRGFIWW361LRCLVINVVL371FILLFFLTTP381AIIITTMDKF391NVTKPVEYLN
401-450401NPIITQFFPT411LLLWCFSALL421PTIVYYSAFF431EAHWTRSGEN441RTTMHKCYTF
451-500451LIFMVLLLPS461LGLSSLDLFF471RWLFDKKFLA481EAAIRFECVF491LPDNGAFFVN
501-550501YVIASAFIGN511AMDLLRIPGL521LMYMIRLCLA531RSAAERRNVK541RHQAYEFQFG
551-600551AAYAWMMCVF561TVVMTYSITC571PIIVPFGLMY581MLLKHLVDRY591NLYYAYLPAK
601-650601LDKKIHSGAV611NQVVAAPILC621LFWLLFFSTM631RTGFLAPTSM641FTFVVLVITI
651-700651VICLCHVCFG661HFKYLSAHNY671KIEHTETDTV681DPRSNGRPPT691AAAVPKSAKY
701-750701IAQVLQDSEV711DGDGDGAPGS721SGDEPPSSSS731QDEELLMPPD741ALTDTDFQSC
751-761751EDSLIENEIH761Q
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 55 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 245 | Prediction (Medium) | - | - |
| 249 | Prediction (Medium) | - | - |
| 250 | Prediction (Medium) | - | - |
| 251 | Prediction (Medium) | - | - |
| 311 | Prediction (Medium) | - | - |
| 313 | Prediction (High) | - | - |
| 528 | Prediction (High) | - | - |
| 653 | Prediction (Low) | - | - |
| 655 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 108 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 128 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 231 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 303 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 394 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 431 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 433 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 542 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 580 | G → C | 0.002033 | SNP | Missense Mutation | THCA |
| 587 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 651 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 702 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 735 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |