Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BM89 | RPL4 | Large ribosomal subunit protein uL4 … | Homo sapiens (Human) | 333 aa |
Protein Details: H3BM89 (RPL4)
Protein Information
| Accession | H3BM89 |
|---|---|
| Protein Names | Large ribosomal subunit protein uL4 (60S ribosomal protein L4) |
| Gene Symbol | RPL4 |
| Organism | Homo sapiens (Human) |
| Length | 333 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MCRGGRMFAP11TKTWRRWHRR21VNTTQKRYAI31CSALAASALP41ALVMSKGHRI
51-10051EEVPELPLVV61EDKVEGYKKT71KEAVLLLKKL81KAWNDIKKVY91ASQRMRAGKG
101-150101KMRNRRRIQR111RGPCIIYNED121NGIIKAFRNI131PGITLLNVSK141LNILKLAPGG
151-200151HVGRFCIWTE161SAFRKLDELY171GTWRKAASLK181SNYNLPMHKM191INTDLSRILK
201-250201SPEIQRALRA211PRKKIHRRVL221KKNPLKNLRI231MLKLNPYAKT241MRRNTILRQA
251-300251RNHKLRVDKA261AAAAAALQAK271SDEKAAVAGK281KPVVGKKGKK291AAVGVKKQKK
301-333301PLVGKKAAAT311KKPAPEKKPA321EKKPTTEEKK331PAA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 2 | Large ribosomal subunit protein uL4 domain superfamily | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.03
|
|
| 31 | Large ribosomal subunit protein uL4, eukaryotic and archaeal type Large ribosomal subunit protein uL4 domain superfamily Large ribosomal subunit protein uL4, eukaryotic/archaeal, conserved site | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.98
|
|
| 114 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.47
|
|
| 156 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
LNCaP
Specificity: 0.667
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.333
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 97 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 143 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 200 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 268 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 336 | R → C | 0.002033 | SNP | Missense Mutation | THCA |
| 342 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |