Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BR18 | SNAP23 | Synaptosomal-associated protein | Homo sapiens (Human) | 109 aa |
Protein Details: H3BR18 (SNAP23)
Protein Information
| Accession | H3BR18 |
|---|---|
| Protein Names | Synaptosomal-associated protein |
| Gene Symbol | SNAP23 |
| Organism | Homo sapiens (Human) |
| Length | 109 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 29575903 31251020 32651440 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDNLSSEEIQ11QRAHQITDES21LESTRRILGL31AIESQDAGIK41TITMLDEQKE
51-10051QLNRIEEGLD61QINKDMRETE71KTLTELNKCC81GLCVCPCNRT91KNFESGKAYK
101-109101TTWGDGGEN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 79 | SWISSPALM DBPTM CYSMODDB | SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.81
Deep-Palm: 0.52
|
| 80 | SWISSPALM DBPTM CYSMODDB | SNAP-25 family |
HeLa
(29575903)
|
Jurkat T
(32651440)
|
GPS-Palm: 0.95
Deep-Palm: 0.55
|
| 83 | SWISSPALM DBPTM CYSMODDB | SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.78
|
| 85 | SWISSPALM DBPTM CYSMODDB | SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.63
|
| 87 | SWISSPALM DBPTM CYSMODDB | SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.94
Deep-Palm: 0.42
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.188
3/3 (100.0%)
2
HeLa cell
Specificity: 0.125
2/2 (100.0%)
1
LNCaP
Specificity: 0.062
1/1 (100.0%)
1
DU145 cell
Specificity: 0.062
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.062
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | Q → Cfs*22 | 0.001887 | INS | Frame Shift Ins | UCEC |
| 142 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |