Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BRF9 | ZFYVE19 | Abscission/NoCut checkpoint regulator (Zinc finger … | Homo sapiens (Human) | 448 aa |
Protein Details: H3BRF9 (ZFYVE19)
Protein Information
| Accession | H3BRF9 |
|---|---|
| Protein Names | Abscission/NoCut checkpoint regulator (Zinc finger FYVE domain-containing protein 19) |
| Gene Symbol | ZFYVE19 |
| Organism | Homo sapiens (Human) |
| Length | 448 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPAVAEALGQ11EGPPDLSRSA21FLATVLTSLS31AAFSSMPSSA41YRSIYPAVLG
51-10051ATMESRCYGC61AVKFTLFKKE71YGCKNCGRAF81CSGCLSFSAA91VPRTGNTQQK
101-150101VCKQCHEVLT111RGSSANASKW121SPPQNYKKRV131AALEAKQKPS141TSQSQGLTRQ
151-200151DQMIAERLAR161LRQENKPKLV171PSQAEIEARL181AALKDERQGS191IPSTQEMEAR
201-250201LAALQGRVLP211SQTPQPAHHT221PDTRTQAQQT231QDLLTQLAAE241VAIDESWKGG
251-300251GPAASLQNDL261NQGGPGSTNS271KRQANWSLEE281EKSRLLAEAA291LELREENTRQ
301-350301ERILALAKRL311AMLRGQDPER321VTLQDYRLPD331SDDDEDEETA341IQRVLQQLTE
351-400351EASLDEASGF361NIPAEQASRP371WTQPRGAEPE381AQDVDPRPEA391EEEELPWCCI
401-448401CNEDATLRCA411GCDGDLFCAR421CFREGHDAFE431LKEHQTSAYS441PPRAGQEH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 57 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.84
|
|
| 60 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.70
|
|
| 73 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.09
|
|
| 76 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.17
|
|
| 81 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.23
|
|
| 84 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.20
|
|
| 102 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.45
|
|
| 105 | - | - | - |
Deep-Palm: 0.40
|
|
| 398 | - | - | - |
Deep-Palm: 0.15
|
|
| 399 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.17
|
|
| 401 | - | - | - |
Deep-Palm: 0.21
|
|
| 409 | - | - | - |
Deep-Palm: 0.06
|
|
| 412 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.04
|
|
| 418 | - | - | - |
Deep-Palm: 0.37
|
|
| 421 | - | - | - |
Deep-Palm: 0.20
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
2
HeLa cell
Specificity: 0.286
2/2 (100.0%)
1
LNCaP
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 125 | C → Sfs*8 | 0.002294 | DEL | Frame Shift Del | OV |
| 136 | S → C | 0.002294 | SNP | Missense Mutation | OV |
| 143 | W → C | 0.002545 | SNP | Missense Mutation | GBM |
| 435 | C → C | 0.003774 | SNP | Silent | UCEC |
| 460 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 466 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |