Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H3BTN5 PKM Pyruvate kinase (EC 2.7.1.40) Homo sapiens (Human) 485 aa

Protein Details: H3BTN5 (PKM)

Protein Information
AccessionH3BTN5
Protein NamesPyruvate kinase (EC 2.7.1.40)
Gene SymbolPKM
OrganismHomo sapiens (Human)
Length485 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MSKPHSEAGT11AFIQTQQLHA21AMADTFLEHM31CRLDIDSPPI41TARNTGIICT
51-10051IGPASRSVET61LKEMIKSGMN71VARLNFSHGT81HEYHAETIKN91VRTATESFAS
101-150101DPILYRPVAV111ALDTKGPEIR121TGLIKGSGTA131EVELKKGATL141KITLDNAYME
151-200151KCDENILWLD161YKNICKVVEV171GSKIYVDDGL181ISLQVKQKGA191DFLVTEVENG
201-250201GSLGSKKGVN211LPGAAVDLPA221VSEKDIQDLK231FGVEQDVDMV241FASFIRKASD
251-300251VHEVRKVLGE261KGKNIKIISK271IENHEGVRRF281DEILEASDGI291MVARGDLGIE
301-350301IPAEKVFLAQ311KMMIGRCNRA321GKPVICATQM331LESMIKKPRP341TRAEGSDVAN
351-400351AVLDGADCIM361LSGETAKGDY371PLEAVRMQHL381IAREAEAAMF391HRKLFEELVR
401-450401ASSHSTDLME411AMAMGSVEAS421YKCLAAALIV431LTESGRSAHQ441VARYRPRAPI
451-485451IAVTRNPQTA461RQAHLYRGIF471PVLCKDPVQE481AWAED
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
31 Pyruvate kinase, C-terminal domain superfamily - -
Deep-Palm: 0.40
49 SWISSPALM DBPTM CYSMODDB Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily Pyruvate kinase, barrel Pyruvate kinase Pyruvate kinase-like domain superfamily Pyruvate kinase barrel domain
HeLa (29575903)
LNCaP (31251020)
GPS-Palm: 0.89
Deep-Palm: 0.84
152 - -
LNCaP (31251020)
Deep-Palm: 0.34
165 - - -
GPS-Palm: 0.72
Deep-Palm: 0.67
317 - - -
GPS-Palm: 0.91
Deep-Palm: 0.89
326 - - -
GPS-Palm: 0.86
Deep-Palm: 0.77
358 SWISSPALM DBPTM CYSMODDB Pyruvate kinase barrel domain
HeLa (29575903)
-
GPS-Palm: 0.81
Deep-Palm: 0.85
423 - - -
GPS-Palm: 0.75
Deep-Palm: 0.96
474 SWISSPALM DBPTM CYSMODDB Pyruvate kinase alpha/beta domain
HeLa (29575903)
-
Deep-Palm: 0.17
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.333
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
3
LNCaP
Specificity: 0.250
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.083
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
32 R → C 0.002288 SNP Missense Mutation STAD
49 C → Y 0.002288 SNP Missense Mutation STAD
92 R → C 0.001887 SNP Missense Mutation UCEC
158 W → C 0.010870 SNP Missense Mutation ACC
298 G → C 0.001887 SNP Missense Mutation UCEC
307 F → C 0.007299 SNP Missense Mutation READ
317 C → Y 0.001014 SNP Missense Mutation BRCA
376 R → C 0.002545 SNP Missense Mutation GBM
467 R → C 0.002288 SNP Missense Mutation STAD
467 R → C 0.002033 SNP Missense Mutation LUSC
516 R → C 0.001887 SNP Missense Mutation UCEC