Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H3BTN5 PKM Pyruvate kinase (EC 2.7.1.40) Homo sapiens (Human) 485 aa

Protein Details: H3BTN5 (PKM)

Protein Information
Accession H3BTN5
Protein Names Pyruvate kinase (EC 2.7.1.40)
Gene Symbol PKM
Organism Homo sapiens (Human)
Length 485 aa
Isoforms No isoforms
Related PMIDs 31251020 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.818
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.818
36/46 (78.3%)
4
PC3 cells
Specificity: 0.091
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.091
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSKPHSEAGT11AFIQTQQLHA21AMADTFLEHM31CRLDIDSPPI41TARNTGIICT
51-10051IGPASRSVET61LKEMIKSGMN71VARLNFSHGT81HEYHAETIKN91VRTATESFAS
101-150101DPILYRPVAV111ALDTKGPEIR121TGLIKGSGTA131EVELKKGATL141KITLDNAYME
151-200151KCDENILWLD161YKNICKVVEV171GSKIYVDDGL181ISLQVKQKGA191DFLVTEVENG
201-250201GSLGSKKGVN211LPGAAVDLPA221VSEKDIQDLK231FGVEQDVDMV241FASFIRKASD
251-300251VHEVRKVLGE261KGKNIKIISK271IENHEGVRRF281DEILEASDGI291MVARGDLGIE
301-350301IPAEKVFLAQ311KMMIGRCNRA321GKPVICATQM331LESMIKKPRP341TRAEGSDVAN
351-400351AVLDGADCIM361LSGETAKGDY371PLEAVRMQHL381IAREAEAAMF391HRKLFEELVR
401-450401ASSHSTDLME411AMAMGSVEAS421YKCLAAALIV431LTESGRSAHQ441VARYRPRAPI
451-485451IAVTRNPQTA461RQAHLYRGIF471PVLCKDPVQE481AWAED
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
49 CYSMODDB SWISSPALM DBPTM Prediction (Medium) Pyruvate kinase barrel domain -
165 Prediction (Low) - -
317 Prediction (High) - -
326 Prediction (Medium) - -
358 CYSMODDB SWISSPALM DBPTM Prediction (Medium) Pyruvate kinase barrel domain -
423 Prediction (Low) - -
474 CYSMODDB SWISSPALM DBPTM Pyruvate kinase alpha/beta domain -
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
32 R → C 0.002288 SNP Missense Mutation STAD
49 C → Y 0.002288 SNP Missense Mutation STAD
92 R → C 0.001887 SNP Missense Mutation UCEC
158 W → C 0.010870 SNP Missense Mutation ACC
298 G → C 0.001887 SNP Missense Mutation UCEC
307 F → C 0.007299 SNP Missense Mutation READ
317 C → Y 0.001014 SNP Missense Mutation BRCA
376 R → C 0.002545 SNP Missense Mutation GBM
467 R → C 0.002288 SNP Missense Mutation STAD
467 R → C 0.002033 SNP Missense Mutation LUSC
516 R → C 0.001887 SNP Missense Mutation UCEC