Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H3BTQ3 SLC19A1 Reduced folate transporter (Solute carrier … Homo sapiens (Human) 545 aa

Protein Details: H3BTQ3 (SLC19A1)

Protein Information
AccessionH3BTQ3
Protein NamesReduced folate transporter (Solute carrier family 19 member 1)
Gene SymbolSLC19A1
OrganismHomo sapiens (Human)
Length545 aa
IsoformsNo isoforms
Related PMIDs 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MVPSSPAVEK11QVPVEPGPDP21ELRSWRHLVC31YLCFYGFMAQ41IRPGESFITP
51-10051YLLGPDKNFT61REQVTNEITP71VLSYSYLAVL81VPVFLLTDYL91RYTPVLLLQG
101-150101LSFVSVWLLL111LLGHSVAHMQ121LMELFYSVTM131AARIAYSSYI141FSLVRPARYQ
151-200151RVAGYSRAAV161LLGVFTSSVL171GQLLVTVGRV181SFSTLNYISL191AFLTFSVVLA
201-250201LFLKRPKRSL211FFNRDDRGRC221ETSASELERM231NPGPGGKLGH241ALRVACGDSV
251-300251LARMLRELGD261SLRRPQLRLW271SLWWVFNSAG281YYLVVYYVHI291LWNEVDPTTN
301-350301SARVYNGAAD311AASTLLGAIT321SFAAGFVKIR331WARWSKLLIA341GVTATQAGLV
351-400351FLLAHTRHPS361SIWLCYAAFV371LFRGSYQFLV381PIATFQIASS391LSKELCALVF
401-450401GVNTFFATIV411KTIITFIVSD421VRGLGLPVRK431QALRMSRPRL441GLCLPGPFPP
451-500451QSAAPARAGM461AASSAEDPGS471ERGPWRRAGT481VAARGDPGGE491RGPWRREGTL
501-545501AARGDPGGER511GPWWREGTLA521VRGDPGGERG531PWRREGTLVV541KGARG
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
30 Reduced folate carrier - -
Deep-Palm: 0.50
33 Reduced folate carrier - -
GPS-Palm: 0.74
Deep-Palm: 0.42
220 - - -
GPS-Palm: 0.76
Deep-Palm: 0.80
246 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.84
Deep-Palm: 0.98
365 - - -
Deep-Palm: 0.68
396 - - -
GPS-Palm: 0.68
Deep-Palm: 0.94
443 - - -
GPS-Palm: 0.88
Deep-Palm: 0.98
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.500
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
83 V → Cfs*121 0.005435 DEL Frame Shift Del ESCA
133 R → C 0.001887 SNP Missense Mutation UCEC
138 S → C 0.003460 SNP Missense Mutation CESC
148 R → C 0.003774 SNP Missense Mutation UCEC
149 Y → C 0.002747 SNP Missense Mutation LIHC
205 R → C 0.001887 SNP Missense Mutation UCEC
229 R → C 0.001887 SNP Missense Mutation UCEC
280 G → C 0.001887 SNP Missense Mutation UCEC
287 Y → C 0.001969 SNP Missense Mutation HNSC
331 W → C 0.001887 SNP Missense Mutation UCEC
333 R → C 0.005435 SNP Missense Mutation ESCA
370 V → Cfs*70 0.002020 DEL Frame Shift Del PRAD
429 R → C 0.002545 SNP Missense Mutation GBM
429 R → C 0.002033 SNP Missense Mutation LUSC