Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H3BV99 | SNAP23 | Synaptosomal-associated protein | Homo sapiens (Human) | 142 aa |
Protein Details: H3BV99 (SNAP23)
Protein Information
| Accession | H3BV99 |
|---|---|
| Protein Names | Synaptosomal-associated protein |
| Gene Symbol | SNAP23 |
| Organism | Homo sapiens (Human) |
| Length | 142 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 29575903 31251020 32651440 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLDEQKEQLN11RIEEGLDQIN21KDMRETEKTL31TELNKCCGLC41VCPCNRTKNF
51-10051ESGKAYKTTW61GDGGENSPCN71VVSKQPGPVT81NGQLQQPTTG91AASGGYIKRI
101-142101TNDAREDEME111ENLTQVGSIL121GNLKDMALNI131GNEIDAQNPQ141IK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 36 | SWISSPALM DBPTM CYSMODDB | SNAP-25 domain SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.81
Deep-Palm: 0.52
|
| 37 | SWISSPALM DBPTM CYSMODDB | SNAP-25 domain SNAP-25 family |
HeLa
(29575903)
|
Jurkat T
(32651440)
|
GPS-Palm: 0.95
Deep-Palm: 0.55
|
| 40 | SWISSPALM DBPTM CYSMODDB | SNAP-25 domain SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.78
|
| 42 | SWISSPALM DBPTM CYSMODDB | SNAP-25 domain SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.95
Deep-Palm: 0.63
|
| 44 | SWISSPALM DBPTM CYSMODDB | SNAP-25 domain SNAP-25 family |
HeLa
(29575903)
| - |
GPS-Palm: 0.94
Deep-Palm: 0.42
|
| 69 | - |
HeLa
(29575903)
|
LNCaP
(31251020)
cerebral cortex
(36430497)
|
Deep-Palm: 0.45
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.286
4
LNCaP
Specificity: 0.211
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.211
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.158
3/3 (100.0%)
2
HeLa cell
Specificity: 0.105
2/2 (100.0%)
1
DU145 cell
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.211
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.053
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | Q → Cfs*22 | 0.001887 | INS | Frame Shift Ins | UCEC |
| 142 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |