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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H7C106 RTN4 Reticulon Homo sapiens (Human) 203 aa

Protein Details: H7C106 (RTN4)

Protein Information
AccessionH7C106
Protein NamesReticulon
Gene SymbolRTN4
OrganismHomo sapiens (Human)
Length203 aa
IsoformsNo isoforms
Related PMIDs 19137006 29575903 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MLCLRTSGRW11RPVWLEARGE21GWGGPWSPVV31DLLYWRDIKK41TGVVFGASLF
51-10051LLLSLTVFSI61VSVTAYIALA71LLSVTISFRI81YKGVIQAIQK91SDEGHPFRAY
101-150101LESEVAISEE111LVQKYSNSAL121GHVNCTIKEL131RRLFLVDDLV141DSLKFAVLMW
151-200151VFTYVGALFN161GLTLLILALI171SLFSVPVIYE181RHQAQIDHYL191GLANKNVKDA
201-203201MAK
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
3 - - -
GPS-Palm: 0.96
Deep-Palm: 0.04
125 SWISSPALM DBPTM CYSMODDB Reticulon
HeLa (29575903)
cerebral cortex (36430497)
GPS-Palm: 0.82
Deep-Palm: 0.96
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.111
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
234 S → C 0.002033 SNP Missense Mutation LUSC
384 Y → C 0.001887 SNP Missense Mutation UCEC
453 G → C 0.001887 SNP Missense Mutation UCEC
732 S → C 0.003460 SNP Missense Mutation CESC
776 F → C 0.005618 SNP Missense Mutation PAAD
848 S → C 0.002294 SNP Missense Mutation OV
895 S → Cfs*6 0.001887 INS Frame Shift Ins UCEC