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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H7C106 RTN4 Reticulon Homo sapiens (Human) 203 aa

Protein Details: H7C106 (RTN4)

Protein Information
Accession H7C106
Protein Names Reticulon
Gene Symbol RTN4
Organism Homo sapiens (Human)
Length 203 aa
Isoforms No isoforms
Related PMIDs 29575903 31251020 32944167
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
20
LNCaP cells
Specificity: 0.800
20/46 (43.5%)
4
PC3 cells
Specificity: 0.160
4/4 (100.0%)
1
HeLa cells
Specificity: 0.040
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLCLRTSGRW11RPVWLEARGE21GWGGPWSPVV31DLLYWRDIKK41TGVVFGASLF
51-10051LLLSLTVFSI61VSVTAYIALA71LLSVTISFRI81YKGVIQAIQK91SDEGHPFRAY
101-150101LESEVAISEE111LVQKYSNSAL121GHVNCTIKEL131RRLFLVDDLV141DSLKFAVLMW
151-200151VFTYVGALFN161GLTLLILALI171SLFSVPVIYE181RHQAQIDHYL191GLANKNVKDA
201-203201MAK
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
3 Prediction (High) - -
125 CYSMODDB SWISSPALM DBPTM Prediction (Medium) Reticulon -
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
234 S → C 0.002033 SNP Missense Mutation LUSC
384 Y → C 0.001887 SNP Missense Mutation UCEC
453 G → C 0.001887 SNP Missense Mutation UCEC
732 S → C 0.003460 SNP Missense Mutation CESC
776 F → C 0.005618 SNP Missense Mutation PAAD
848 S → C 0.002294 SNP Missense Mutation OV
895 S → Cfs*6 0.001887 INS Frame Shift Ins UCEC