Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H7C131 | ACAA1 | acetyl-CoA C-acetyltransferase (EC 2.3.1.9) | Homo sapiens (Human) | 290 aa |
Protein Details: H7C131 (ACAA1)
Protein Information
| Accession | H7C131 |
|---|---|
| Protein Names | acetyl-CoA C-acetyltransferase (EC 2.3.1.9) |
| Gene Symbol | ACAA1 |
| Organism | Homo sapiens (Human) |
| Length | 290 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32651440 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRPEQLGDIC11VGNVLQPGAG21AIMARIAQFL31SDIPETVPLS41TVNRQCSSGL
51-10051QAVASIAGGI61RNGSYDIGMA71CGITSENVAE81RFGISREKQD91TFALASQQKA
101-150101ARAQSKGCFQ111AEIVPVTTTV121HDDKGTKRSI131TVTQDEGIRP141STTMEGLAKL
151-200151KPAFKKDGST161TAGNSSQVSD171GAAAILLARR181SKAEELGLPI191LGVLRSYAVV
201-250201GVPPDIMGIG211PAYAIPVALQ221KAGLTVSDVD231IFEINEAFAS241QAAYCVEKLR
251-290251LPPEKVNPLG261GAVALGHPLG271CTGARQVITL281LNELKRRGKR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.30
|
|
| 46 | Thiolase, N-terminal Thiolase-like Thiolase-like superfamily, Thiolase | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.97
|
|
| 71 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.82
|
|
| 108 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.85
|
|
| 245 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.98
|
|
| 271 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.333
3/3 (100.0%)
1
U937 cell
Specificity: 0.111
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
Cerebral Cortex (Mass)
Specificity: 0.333
3/4 (75.0%)
1
LNCaP cells (Mass)
Specificity: 0.111
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 123 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 396 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |