Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H7C5I5 | PLSCR1 | Phospholipid scramblase | Homo sapiens (Human) | 171 aa |
Protein Details: H7C5I5 (PLSCR1)
Protein Information
| Accession | H7C5I5 |
|---|---|
| Protein Names | Phospholipid scramblase |
| Gene Symbol | PLSCR1 |
| Organism | Homo sapiens (Human) |
| Length | 171 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29575903 32651440 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XGFPVPNQPV11YNQPVYNQPV21GAAGVPWMPA31PQPPLNCPPG41LEYLSQIDQI
51-10051LIHQQIELLE61EIQAPPGVPI71GYVIQTWHPC81LPKFTIQNEK91REDVLKISGP
101-150101CVVCSCCGDV111DFEIKSLDEQ121CVVGKISKHW131TGILREAFTD141ADNFGIQFPL
151-171151DLDVKMKAVM161IGACFLIDFM171F
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 37 | Scramblase | - | - |
Deep-Palm: 0.77
|
|
| 80 | SWISSPALM DBPTM CYSMODDB | Scramblase |
HeLa
(29575903)
| - |
GPS-Palm: 0.85
Deep-Palm: 0.83
|
| 101 | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.43
|
|
| 104 | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.52
|
|
| 106 | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.69
Deep-Palm: 0.23
|
|
| 107 | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.18
|
|
| 121 | - |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.67
Deep-Palm: 0.93
|
|
| 164 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
1
HeLa cell
Specificity: 0.067
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
1
DU145 cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 21 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 55 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 134 | S → delinsILNC | 0.001887 | INS | In Frame Ins | UCEC |
| 169 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 181 | C → Y | 0.002545 | SNP | Missense Mutation | GBM |
| 188 | C → C | 0.002294 | SNP | Silent | OV |
| 210 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 213 | C → Y | 0.001764 | SNP | Missense Mutation | LUAD |
| 254 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |