Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H7C5K2 | STIM2 | Stromal interaction molecule 2 | Homo sapiens (Human) | 347 aa |
Protein Details: H7C5K2 (STIM2)
Protein Information
| Accession | H7C5K2 |
|---|---|
| Protein Names | Stromal interaction molecule 2 |
| Gene Symbol | STIM2 |
| Organism | Homo sapiens (Human) |
| Length | 347 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501EINYAKEEAC11RLRELREGAE21CELSRRQYAE31QELEQVRMAL41KKAEKEFELR
51-10051SSWSVPDALQ61KWLQLTHEVE71VQYYNIKRQN81AEMQLAIAKD91EAEKIKKKRS
101-150101TVFGTLHVAH111SSSLDEVDHK121ILEAKKALSE131LTTCLRERLF141RWQQIEKICG
151-200151FQIAHNSGLP161SLTSSLYSDH171SWVVMPRVSI181PPYPIAGGVD191DLDEDTPPIV
201-250201SQFPGTMAKP211PGSLARSSSL221CRSRRSIVPS231SPQPQRAQLA241PHAPHPSHPR
251-300251HPHHPQHTPH261SLPSPDPDIL271SVSSCPALYR281NEEEEEAIYF291SAEKQWNTRE
301-347301CAVGDSQGPH311VHGLVRFDKD321FGSYSEYERK331HWEVSRKCQT341QLQNVTP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.21
|
| 21 | Stromal interaction molecule | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 134 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.97
|
|
| 149 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.84
|
|
| 221 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.94
|
|
| 275 | - | - | - |
Deep-Palm: 0.78
|
|
| 301 | - | - | - |
Deep-Palm: 0.65
|
|
| 338 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
LNCaP
Specificity: 0.667
4/4 (100.0%)
2
PC3
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 318 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 433 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 433 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 516 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 597 | C → C | 0.002288 | SNP | Silent | STAD |
| 647 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 694 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |