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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
H9KV75 ACTN1 F-actin cross-linking protein Homo sapiens (Human) 822 aa

Protein Details: H9KV75 (ACTN1)

Protein Information
Accession H9KV75
Protein Names F-actin cross-linking protein
Gene Symbol ACTN1
Organism Homo sapiens (Human)
Length 822 aa
Isoforms No isoforms
Related PMIDs 31251020 31382980 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.793
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
23
LNCaP cells
Specificity: 0.793
23/46 (50.0%)
4
PC3 cells
Specificity: 0.138
4/4 (100.0%)
1
U937 cells
Specificity: 0.034
1/1 (100.0%)
1
Cerebral cortex
Specificity: 0.034
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLLLEVISGE11RLAKPERGKM21RVHKISNVNK31ALDFIASKGV41KLVSIGAEEI
51-10051VDGNVKMTLG61MIWTIILRFA71IQDISVEETS81AKEGLLLWCQ91RKTAPYKNVN
101-150101IQNFHISWKD111GLGFCALIHR121HRPELIDYGK131LRKDDPLTNL141NTAFDVAEKY
151-200151LDIPKMLDAE161DIVGTARPDE171KAIMTYVSSF181YHAFSGAQKA191ETAANRICKV
201-250201LAVNQENEQL211MEDYEKLASD221LLEWIRRTIP231WLENRVPENT241MHAMQQKLED
251-300251FRDYRRLHKP261PKVQEKCQLE271INFNTLQTKL281RLSNRPAFMP291SEGRMVSDIN
301-350301NAWGCLEQVE311KGYEEWLLNE321IRRLERLDHL331AEKFRQKASI341HEAWTDGKEA
351-400351MLRQKDYETA361TLSEIKALLK371KHEAFESDLA381AHQDRVEQIA391AIAQELNELD
401-450401YYDSPSVNAR411CQKICDQWDN421LGALTQKRRE431ALERTEKLLE441TIDQLYLEYA
451-500451KRAAPFNNWM461EGAMEDLQDT471FIVHTIEEIQ481GLTTAHEQFK491ATLPDADKER
501-550501LAILGIHNEV511SKIVQTYHVN521MAGTNPYTTI531TPQEINGKWD541HVRQLVPRRD
551-600551QALTEEHARQ561QHNERLRKQF571GAQANVIGPW581IQTKMEEIGR591ISIEMHGTLE
601-650601DQLSHLRQYE611KSIVNYKPKI621DQLEGDHQLI631QEALIFDNKH641TNYTMEHIRV
651-700651GWEQLLTTIA661RTINEVENQI671LTRDAKGISQ681EQMNEFRASF691NHFDRKKTGM
701-750701MDTDDFRACL711ISMGYNMGEA721EFARIMSIVD731PNRLGVVTFQ741AFIDFMSRET
751-800751ADTDTADQVM761ASFKILAGDK771NYITMDELRR781ELPPDQAEYC791IARMAPYTGP
801-822801DSVPGALDYM811SFSTALYGES821DL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
89 CYSMODDB SWISSPALM DBPTM Prediction (High) Calponin homology (CH) domain -
115 Prediction (High) - -
198 Prediction (Medium) - -
267 CYSMODDB SWISSPALM DBPTM - -
415 Prediction (Low) - -
709 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
41 C → C 0.001887 SNP Silent UCEC
250 S → C 0.002427 SNP Missense Mutation BLCA
321 R → C 0.001887 SNP Missense Mutation UCEC
377 G → C 0.001764 SNP Missense Mutation LUAD
480 C → Y 0.001887 SNP Missense Mutation UCEC
632 R → C 0.001887 SNP Missense Mutation UCEC
714 R → C 0.002506 SNP Missense Mutation COAD
717 W → C 0.001887 SNP Missense Mutation UCEC
803 R → C 0.001887 SNP Missense Mutation UCEC
849 R → C 0.003774 SNP Missense Mutation UCEC
850 R → C 0.002506 SNP Missense Mutation COAD
850 R → C 0.001887 SNP Missense Mutation UCEC