Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| J3KPS3 | ALDOA | Fructose-bisphosphate aldolase (EC 4.1.2.13) | Homo sapiens (Human) | 368 aa |
Protein Details: J3KPS3 (ALDOA)
Protein Information
| Accession | J3KPS3 |
|---|---|
| Protein Names | Fructose-bisphosphate aldolase (EC 4.1.2.13) |
| Gene Symbol | ALDOA |
| Organism | Homo sapiens (Human) |
| Length | 368 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPYQYPALTP11EQKKELSDIA21HRIVAPGKGI31LAADESTGSI41AKRLQSIGTE
51-10051NTEENRRFYR61QLLLTADDRV71NPCIGGVILF81HETLYQKADD91GRPFPQVIKS
101-150101KGGVVGIKVD111KGVVPLAGTN121GETTTQGLDG131LSERCAQYKK141DGADFAKWRC
151-200151VLKIGEHTPS161ALAIMENANV171LARYASICQQ181VGLQNGIVPI191VEPEILPDGD
201-250201HDLKRCQYVT211EKVLAAVYKA221LSDHHIYLEG231TLLKPNMVTP241GHACTQKFSH
251-300251EEIAMATVTA261LRRTVPPAVT271GITFLSGGQS281EEEASINLNA291INKCPLLKPW
301-350301ALTFSYGRAL311QASALKAWGG321KKENLKAAQE331EYVKRALANS341LACQGKYTPS
351-368351GQAGAAASES361LFVSNHAY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 73 | SWISSPALM DBPTM CYSMODDB | Fructose-bisphosphate aldolase class-I |
HeLa
(29575903)
| - |
GPS-Palm: 0.80
Deep-Palm: 0.81
|
| 135 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 150 | - | - | - |
Deep-Palm: 0.90
|
|
| 178 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.77
|
|
| 206 | - | - | - |
Deep-Palm: 0.96
|
|
| 244 | - | - | - |
Deep-Palm: 0.62
|
|
| 294 | SWISSPALM DBPTM CYSMODDB | Fructose-bisphosphate aldolase class-I |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.95
|
| 343 | SWISSPALM DBPTM CYSMODDB | Fructose-bisphosphate aldolase class-I |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
2
LNCaP
Specificity: 0.133
2/2 (100.0%)
1
U937 cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 76 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 149 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 201 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 201 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 204 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |