Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| J3KRZ1 | DDX5 | DEAD-box helicase 5 | Homo sapiens (Human) | 166 aa |
Protein Details: J3KRZ1 (DDX5)
Protein Information
| Accession | J3KRZ1 |
|---|---|
| Protein Names | DEAD-box helicase 5 |
| Gene Symbol | DDX5 |
| Organism | Homo sapiens (Human) |
| Length | 166 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501ERGDGPICLV11LAPTRELAQQ21VQQVAAEYCR31ACRLKSTCIY41GGAPKGPQIR
51-10051DLERGVEICI61ATPGRLIDFL71ECGKTNLRRT81TYLVLDEADR91MLDMGFEPQI
101-150101RKIVDQIRPD111RQTLMWSATW121PKEVRQLAED131FLKDYIHINI141GALELSANHN
151-166151ILQIVDVCHD161VEKDEK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | P-loop containing nucleoside triphosphate hydrolase | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.36
|
|
| 29 | DEAD/DEAH box helicase domain P-loop containing nucleoside triphosphate hydrolase ATP-DEPENDENT RNA HELICASE DBP3 | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.70
Deep-Palm: 0.92
|
|
| 32 | DEAD/DEAH box helicase domain P-loop containing nucleoside triphosphate hydrolase ATP-DEPENDENT RNA HELICASE DBP3 | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.84
|
|
| 38 | DEAD/DEAH box helicase domain P-loop containing nucleoside triphosphate hydrolase ATP-DEPENDENT RNA HELICASE DBP3 | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.88
|
|
| 59 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.96
|
| 72 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 158 | - | - | - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
3
PC3
Specificity: 0.500
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 191 | C → G | 0.002427 | SNP | Missense Mutation | BLCA |
| 331 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 461 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 482 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 493 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 497 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 526 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |