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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
J3KS13 CLTC Clathrin heavy chain Homo sapiens (Human) 612 aa

Protein Details: J3KS13 (CLTC)

Protein Information
AccessionJ3KS13
Protein NamesClathrin heavy chain
Gene SymbolCLTC
OrganismHomo sapiens (Human)
Length612 aa
IsoformsNo isoforms
Related PMIDs 19137006 21076176 26876311 29575903 31251020 32944167 36430497
Database SourcesNo database sources
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAQILPIRFQ11EHLQLQNLGI21NPANIGFSTL31TMESDKFICI41REKVGEQAQV
51-10051VIIDMNDPSN61PIRRPISADS71AIMNPASKVI81ALKAGKTLQI91FNIEMKSKMK
101-150101ARESYVETEL111IFALAKTNRL121AELEEFINGP131NNAHIQQVGD141RCYDEKMYDA
151-200151AKLLYNNVSN161FGRLASTLVH171LGEYQAAVDG181ARKANSTRTW191KEVCFACVDG
201-250201KEFRLAQMCG211LHIVVHADEL221EELINYYQDR231GYFEELITML241EAALGLERAH
251-300251MGMFTELAIL261YSKFKPQKMR271EHLELFWSRV281NIPKVLRAAE291QAHLWAELVF
301-350301LYDKYEEYDN311AIITMMNHPT321DAWKEGQFKD331IITKVANVEL341YYRAIQFYLE
351-400351FKPLLLNDLL361MVLSPRLDHT371RAVNYFSKVK381QLPLVKPYLR391SVQNHNNKSV
401-450401NESLNNLFIT411EEDYQALRTS421IDAYDNFDNI431SLAQRLEKHE441LIEFRRIAAY
451-500451LFKGNNRWKQ461SVELCKKDSL471YKDAMQYASE481SKDTELAEEL491LQWFLQEEKR
501-550501ECFGACLFTC511YDLLRPDVVL521ETAWRHNIMD531FAMPYFIQVM541KEYLTKVDKL
551-600551DASESLRKEE561EQATETQPIV571YGQPQLMLTA581GPSVAVPPQA591PFGYGYTAPP
601-612601YGQPQPGFGY611SM
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
39 CLATHRIN HEAVY CHAIN RELATED Clathrin heavy chain, N-terminal Clathrin, heavy chain, propeller repeat - -
GPS-Palm: 0.73
Deep-Palm: 0.87
142 - - -
Deep-Palm: 0.08
194 - -
cerebral cortex (36430497)
GPS-Palm: 0.84
Deep-Palm: 0.76
197 - -
cerebral cortex (36430497)
GPS-Palm: 0.77
Deep-Palm: 0.50
209 - - -
GPS-Palm: 0.77
Deep-Palm: 0.86
465 - - -
GPS-Palm: 0.80
Deep-Palm: 0.70
502 - - -
GPS-Palm: 0.70
Deep-Palm: 0.80
506 - - -
Deep-Palm: 0.71
510 - - -
Deep-Palm: 0.94
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
3
LNCaP
Specificity: 0.200
3/3 (100.0%)
2
Jurkat T cell
Specificity: 0.133
2/2 (100.0%)
1
HeLa cell
Specificity: 0.067
1/1 (100.0%)
1
frontal cortex
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
176 R → C 0.007299 SNP Missense Mutation READ
294 Y → C 0.001887 SNP Missense Mutation UCEC
305 V → Cfs*6 0.002976 INS Frame Shift Ins KIRC
328 C → Ffs*9 0.002747 DEL Frame Shift Del LIHC
354 R → C 0.002506 SNP Missense Mutation COAD
655 F → C 0.001969 SNP Missense Mutation LGG
895 R → C 0.002506 SNP Missense Mutation COAD
903 R → C 0.002506 SNP Missense Mutation COAD
903 R → C 0.001887 SNP Missense Mutation UCEC
923 R → C 0.001887 SNP Missense Mutation UCEC
1189 F → C 0.001887 SNP Missense Mutation UCEC
1210 M → Cfs*52 0.002506 DEL Frame Shift Del COAD
1289 Y → C 0.002294 SNP Missense Mutation OV
1544 S → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.001014 SNP Missense Mutation BRCA