Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7EJ44 | PFN1 | Profilin | Homo sapiens (Human) | 104 aa |
Protein Details: K7EJ44 (PFN1)
Protein Information
| Accession | K7EJ44 |
|---|---|
| Protein Names | Profilin |
| Gene Symbol | PFN1 |
| Organism | Homo sapiens (Human) |
| Length | 104 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGAWFLFQPA11EVGVLVGKDR21SSFYVNGLTL31GGQKCSVIRD41SLLQDGEFSM
51-10051DLRTKSTGGA61PTFNVTVTKT71DKTLVLLMGK81EGVHGGLINK91KCYEMASHLR
101-104101RSQY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 35 | Profilin superfamily Profilin1/2/3, vertebrate PROFILIN Dynein light chain 2a, cytoplasmic | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.92
|
|
| 92 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.71
Deep-Palm: 0.06
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.667
4/4 (100.0%)
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 17 | C → _D27del | 0.002288 | DEL | In Frame Del | STAD |
| ? | ? → ? | 0.002427 | SNP | Missense Mutation | BLCA |