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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
K7EJE8 LONP1 Lon protease homolog, mitochondrial (EC … Homo sapiens (Human) 829 aa

Protein Details: K7EJE8 (LONP1)

Protein Information
Accession K7EJE8
Protein Names Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)
Gene Symbol LONP1
Organism Homo sapiens (Human)
Length 829 aa
Isoforms No isoforms
Related PMIDs 29575903 31251020 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.900
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.900
36/46 (78.3%)
2
PC3 cells
Specificity: 0.050
2/4 (50.0%)
2
Cerebral cortex
Specificity: 0.050
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTIPDVFPHL11PLIAITRNPV21FPRFIKIIEV31KNKKLVELLR41RKVRLAQPYV
51-10051GVFLKRDDSN61ESDVVESLDE71IYHTGTFAQI81HEMQDLGDKL91RMIVMGHRRV
101-150101HISRQLEVEP111EEPEAENKHK121PRRKSKRGKK131EAEDELSARH141PAELAMEPTP
151-200151ELPAEVLMVE161ALTAEIVKTI171RDIIALNPLY181RESVLQMMQA191GQRVVDNPIY
201-250201LSDMGAALTG211AESHELQDVL221EETNIPKRLY231KALSLLKKEF241ELSKLQQRLG
251-300251REVEEKIKQT261HRKYLLQEQL271KIIKKELGLE281KDDKDAIEEK291FRERLKELVV
301-350301PKHVMDVVDE311ELSKLGLLDN321HSSEFNVTRN331YLDWLTSIPW341GKYSNENLDL
351-400351ARAQAVLEED361HYGMEDVKKR371ILEFIAVSQL381RGSTQGKILC391FYGPPGVGKT
401-450401SIARSIARAL411NREYFRFSVG421GMTDVAEIKG431HRRTYVGAMP441GKIIQCLKKT
451-500451KTENPLILID461EVDKIGRGYQ471GDPSSALLEL481LDPEQNANFL491DHYLDVPVDL
501-550501SKVLFICTAN511VTDTIPEPLR521DRMEMINVSG531YVAQEKLAIA541ERYLVPQARA
551-600551LCGLDESKAK561LSSDVLTLLI571KQYCRESGVR581NLQKQVEKVL591RKSAYKIVSG
601-650601EAESVEVTPE611NLQDFVGKPV621FTVERMYDVT631PPGVVMGLAW641TAMGGSTLFV
651-700651ETSLRRPQDK661DAKGDKDGSL671EVTGQLGEVM681KESARIAYTF691ARAFLMQHAP
701-750701ANDYLVTSHI711HLHVPEGATP721KDGPSAGCTI731VTALLSLAMG741RPVRQNLAMT
751-800751GEVSLTGKIL761PVGGIKEKTI771AAKRAGVTCI781VLPAENKKDF791YDLAAFITEG
801-829801LEVHFVEHYR811EIFDIAFPDE821QAEALAVER
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
390 Prediction (High) - -
446 Prediction (High) - -
507 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) - 29575903
552 Prediction (High) - -
574 Prediction (Medium) - -
779 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
158 R → C 0.002427 SNP Missense Mutation BLCA
158 R → C 0.005660 SNP Missense Mutation UCEC
424 R → C 0.001887 SNP Missense Mutation UCEC
473 Y → C 0.001969 SNP Missense Mutation HNSC
500 R → C 0.002288 SNP Missense Mutation STAD
815 R → C 0.005618 SNP Missense Mutation PAAD
853 G → C 0.002033 SNP Missense Mutation LUSC