Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7EK04 | PLEKHH3 | Pleckstrin homology, MyTH4 and FERM … | Homo sapiens (Human) | 206 aa |
Protein Details: K7EK04 (PLEKHH3)
Protein Information
| Accession | K7EK04 |
|---|---|
| Protein Names | Pleckstrin homology, MyTH4 and FERM domain containing H3 |
| Gene Symbol | PLEKHH3 |
| Organism | Homo sapiens (Human) |
| Length | 206 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPLPGGLWWL11LCCRRGFTLL21HRDYGDGELS31GDGDEDEDEE41TFELRTPSPA
51-10051GGGRGGSVEE61GKMRRRGCLG71AWQNELTSPV81SKMGKLRPGD91GKRLAQGSTG
101-150101PLEVTLTQPV111RSGPVSNRLQ121SWEETWSLIP131EKGLPEDDPD141IVVKGWLYRE
151-200151PRGGGARPWL161PPRRAWFVLT171RDSLDQFSSS181GKGARRLGSL191VLTSLCSVTG
201-206201PERRRK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.16
|
| 13 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.50
|
| 68 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.94
|
|
| 196 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 189 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 516 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 757 | S → C | 0.002288 | SNP | Missense Mutation | STAD |