Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7EKE6 | LONP1 | Lon protease homolog, mitochondrial (EC … | Homo sapiens (Human) | 845 aa |
Protein Details: K7EKE6 (LONP1)
Protein Information
| Accession | K7EKE6 |
|---|---|
| Protein Names | Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) |
| Gene Symbol | LONP1 |
| Organism | Homo sapiens (Human) |
| Length | 845 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTIPDVFPHL11PLIAITRNPV21FPRFIKIIEV31KNKKLVELLR41RKVRLAQPYV
51-10051GVFLKRDDSN61ESDVVESLDE71IYHTGTFAQI81HEMQDLGDKL91RMIVMGHRRV
101-150101HISRQLEVEP111EEPEAENKHK121PRRKSKRGKK131EAEDELSARH141PAELAMEPTP
151-200151ELPAEVLMVE161VENVVHEDFQ171VTEEVKALTA181EIVKTIRDII191ALNPLYRESV
201-250201LQMMQAGQRV211VDNPIYLSDM221GAALTGAESH231ELQDVLEETN241IPKRLYKALS
251-300251LLKKEFELSK261LQQRLGREVE271EKIKQTHRKY281LLQEQLKIIK291KELGLEKDDK
301-350301DAIEEKFRER311LKELVVPKHV321MDVVDEELSK331LGLLDNHSSE341FNVTRNYLDW
351-400351LTSIPWGKYS361NENLDLARAQ371AVLEEDHYGM381EDVKKRILEF391IAVSQLRGST
401-450401QGKILCFYGP411PGVGKTSIAR421SIARALNREY431FRFSVGGMTD441VAEIKGHRRT
451-500451YVGAMPGKII461QCLKKTKTEN471PLILIDEVDK481IGRGYQGDPS491SALLELLDPE
501-550501QNANFLDHYL511DVPVDLSKVL521FICTANVTDT531IPEPLRDRME541MINVSGYVAQ
551-600551EKLAIAERYL561VPQARALCGL571DESKAKLSSD581VLTLLIKQYC591RESGVRNLQK
601-650601QVEKVLRKSA611YKIVSGEAES621VEVTPENLQD631FVGKPVFTVE641RMYDVTPPGV
651-700651VMGLAWTAMG661GSTLFVETSL671RRPQDKDAKG681DKDGSLEVTG691QLGEVMKESA
701-750701RIAYTFARAF711LMQHAPANDY721LVTSHIHLHV731PEGATPKDGP741SAGCTIVTAL
751-800751LSLAMGRPVR761QNLAMTGEVS771LTGKILPVGG781IKEKTIAAKR791AGVTCIVLPA
801-845801ENKKDFYDLA811AFITEGLEVH821FVEHYREIFD831IAFPDEQAEA841LAVER
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 406 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 462 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 523 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.74
Deep-Palm: 0.97
|
| 568 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.98
|
|
| 590 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 744 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.97
|
|
| 795 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.400
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 158 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 158 | R → C | 0.005660 | SNP | Missense Mutation | UCEC |
| 424 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 473 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 500 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 815 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 853 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |