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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
K7EKE6 LONP1 Lon protease homolog, mitochondrial (EC … Homo sapiens (Human) 845 aa

Protein Details: K7EKE6 (LONP1)

Protein Information
Accession K7EKE6
Protein Names Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)
Gene Symbol LONP1
Organism Homo sapiens (Human)
Length 845 aa
Isoforms No isoforms
Related PMIDs 31251020 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.900
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.900
36/46 (78.3%)
2
PC3 cells
Specificity: 0.050
2/4 (50.0%)
2
Cerebral cortex
Specificity: 0.050
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTIPDVFPHL11PLIAITRNPV21FPRFIKIIEV31KNKKLVELLR41RKVRLAQPYV
51-10051GVFLKRDDSN61ESDVVESLDE71IYHTGTFAQI81HEMQDLGDKL91RMIVMGHRRV
101-150101HISRQLEVEP111EEPEAENKHK121PRRKSKRGKK131EAEDELSARH141PAELAMEPTP
151-200151ELPAEVLMVE161VENVVHEDFQ171VTEEVKALTA181EIVKTIRDII191ALNPLYRESV
201-250201LQMMQAGQRV211VDNPIYLSDM221GAALTGAESH231ELQDVLEETN241IPKRLYKALS
251-300251LLKKEFELSK261LQQRLGREVE271EKIKQTHRKY281LLQEQLKIIK291KELGLEKDDK
301-350301DAIEEKFRER311LKELVVPKHV321MDVVDEELSK331LGLLDNHSSE341FNVTRNYLDW
351-400351LTSIPWGKYS361NENLDLARAQ371AVLEEDHYGM381EDVKKRILEF391IAVSQLRGST
401-450401QGKILCFYGP411PGVGKTSIAR421SIARALNREY431FRFSVGGMTD441VAEIKGHRRT
451-500451YVGAMPGKII461QCLKKTKTEN471PLILIDEVDK481IGRGYQGDPS491SALLELLDPE
501-550501QNANFLDHYL511DVPVDLSKVL521FICTANVTDT531IPEPLRDRME541MINVSGYVAQ
551-600551EKLAIAERYL561VPQARALCGL571DESKAKLSSD581VLTLLIKQYC591RESGVRNLQK
601-650601QVEKVLRKSA611YKIVSGEAES621VEVTPENLQD631FVGKPVFTVE641RMYDVTPPGV
651-700651VMGLAWTAMG661GSTLFVETSL671RRPQDKDAKG681DKDGSLEVTG691QLGEVMKESA
701-750701RIAYTFARAF711LMQHAPANDY721LVTSHIHLHV731PEGATPKDGP741SAGCTIVTAL
751-800751LSLAMGRPVR761QNLAMTGEVS771LTGKILPVGG781IKEKTIAAKR791AGVTCIVLPA
801-845801ENKKDFYDLA811AFITEGLEVH821FVEHYREIFD831IAFPDEQAEA841LAVER
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
406 Prediction (High) - -
462 Prediction (High) - -
523 CYSMODDB SWISSPALM DBPTM Prediction (Low) - -
568 Prediction (High) - -
590 Prediction (Medium) - -
795 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
158 R → C 0.002427 SNP Missense Mutation BLCA
158 R → C 0.005660 SNP Missense Mutation UCEC
424 R → C 0.001887 SNP Missense Mutation UCEC
473 Y → C 0.001969 SNP Missense Mutation HNSC
500 R → C 0.002288 SNP Missense Mutation STAD
815 R → C 0.005618 SNP Missense Mutation PAAD
853 G → C 0.002033 SNP Missense Mutation LUSC