Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7EQ23 | NPC1 | NPC intracellular cholesterol transporter 1 | Homo sapiens (Human) | 971 aa |
Protein Details: K7EQ23 (NPC1)
Protein Information
| Accession | K7EQ23 |
|---|---|
| Protein Names | NPC intracellular cholesterol transporter 1 |
| Gene Symbol | NPC1 |
| Organism | Homo sapiens (Human) |
| Length | 971 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29575903 32651440 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
2
DU145 cells
Specificity: 0.667
2/2 (100.0%)
1
Jurkat T cells
Specificity: 0.333
1/25 (4.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501XAPWTILGLD11AMYVIMWITY21MAFLLVFFGA31FFAVWCYRKR41YFVSEYTPID
51-10051SNIAFSVNAS61DKGTAWLLTS71TFPSSPVLPG81EASCCDPVSA91AFEGCLRRLF
101-150101TRWGSFCVRN111PGCVIFFSLV121FITACSSGLV131FVRVTTNPVD141LWSAPSSQAR
151-200151LEKEYFDQHF161GPFFRTEQLI171IRAPLTDKHI181YQPYPSGADV191PFGPPLDIQI
201-250201LHQVLDLQIA211IENITASYDN221ETVTLQDICL231APLSPYNTNC241TILSVLNYFQ
251-300251NSHSVLDHKK261GDDFFVYADY271HTHFLYCVRF281INFVKNYKNP291NLTISFTAER
301-350301SIEDELNRES311DSDVFTVVIS321YAIMFLYISL331ALGHMKSCRR341LLVDSKVSLG
351-400351IAGILIVLSS361VACSLGVFSY371IGLPLTLIVI381EVIPFLVLAV391GVDNIFILVQ
401-450401AYQRDERLQG411ETLDQQLGRV421LGEVAPSMFL431SSFSETVAFF441LGALSVMPAV
451-500451HTFSLFAGLA461VFIDFLLQIT471CFVSLLGLDI481KRQEKNRLDI491FCCVRGAEDG
501-550501TSVQASESCL511FRFFKNSYSP521LLLKDWMRPI531VIAIFVGVLS541FSIAVLNKVD
551-600551IGLDQSLSMP561DDSYMVDYFK571SISQYLHAGP581PVYFVLEEGH591DYTSSKGQNM
601-650601VCGGMGCNND611SLVQQIFNAA621QLDNYTRIGF631APSSWIDDYF641DWVKPQSSCC
651-700651RVDNITDQFC661NASVVDPACV671RCRPLTPEGK681QRPQGGDFMR691FLPMFLSDNP
701-750701NPKCGKGGHA711AYSSAVNILL721GHGTRVGATY731FMTYHTVLQT741SADFIDALKK
751-800751ARLIASNVTE761TMGINGSAYR771VFPYSVFYVF781YEQYLTIIDD791TIFNLGVSLG
801-850801AIFLVTMVLL811GCELWSAVIM821CATIAMVLVN831MFGVMWLWGI841SLNAVSLVNL
851-900851VMSCGISVEF861CSHITRAFTV871SMKGSRVERA881EEALAHMGSS891VFSGITLTKF
901-950901GGIVVLAFAK911SQIFQIFYFR921MYLAMVLLGA931THGLIFLPVL941LSYIGPSVNK
951-971951AKSCATEERY961KGTERERLLN971F
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 36 | Prediction (Medium) | - | - |
| 95 | Prediction (High) | - | - |
| 107 | Prediction (High) | - | - |
| 113 | Prediction (Low) | - | - |
| 125 | Prediction (Medium) | - | - |
| 338 | Prediction (High) | - | - |
| 363 | Prediction (Low) | - | - |
| 492 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | Sterol-sensing domain of SREBP cleavage-activation | 29575903 |
| 493 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | Sterol-sensing domain of SREBP cleavage-activation | 29575903 |
| 509 | Prediction (Medium) | - | - |
| 602 | Prediction (Low) | - | - |
| 649 | Prediction (Low) | - | - |
| 650 | Prediction (Low) | - | - |
| 669 | Prediction (Low) | - | - |
| 672 | Prediction (Low) | - | - |
| 861 | Prediction (Low) | - | - |
| 954 | Prediction (Medium) | - | - |
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 146 | Y → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 346 | C → C | 0.002506 | SNP | Silent | COAD |
| 570 | Y → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 714 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 763 | F → Cfs*8 | 0.002506 | DEL | Frame Shift Del | COAD |
| 799 | C → Lfs*7 | 0.002506 | INS | Frame Shift Ins | COAD |
| 909 | C → C | 0.001014 | SNP | Silent | BRCA |
| 909 | C → C | 0.002288 | SNP | Silent | STAD |
| 998 | F → C | 0.002294 | SNP | Missense Mutation | OV |
| 1146 | G → C | 0.006993 | SNP | Missense Mutation | LAML |
| 799* | C → ? | 0.005618 | SNP | Nonsense Mutation | PAAD |