Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7EQ23 | NPC1 | NPC intracellular cholesterol transporter 1 | Homo sapiens (Human) | 971 aa |
Protein Details: K7EQ23 (NPC1)
Protein Information
| Accession | K7EQ23 |
|---|---|
| Protein Names | NPC intracellular cholesterol transporter 1 |
| Gene Symbol | NPC1 |
| Organism | Homo sapiens (Human) |
| Length | 971 aa |
| Isoforms | No isoforms |
| Related PMIDs | 32651440 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XAPWTILGLD11AMYVIMWITY21MAFLLVFFGA31FFAVWCYRKR41YFVSEYTPID
51-10051SNIAFSVNAS61DKGTAWLLTS71TFPSSPVLPG81EASCCDPVSA91AFEGCLRRLF
101-150101TRWGSFCVRN111PGCVIFFSLV121FITACSSGLV131FVRVTTNPVD141LWSAPSSQAR
151-200151LEKEYFDQHF161GPFFRTEQLI171IRAPLTDKHI181YQPYPSGADV191PFGPPLDIQI
201-250201LHQVLDLQIA211IENITASYDN221ETVTLQDICL231APLSPYNTNC241TILSVLNYFQ
251-300251NSHSVLDHKK261GDDFFVYADY271HTHFLYCVRF281INFVKNYKNP291NLTISFTAER
301-350301SIEDELNRES311DSDVFTVVIS321YAIMFLYISL331ALGHMKSCRR341LLVDSKVSLG
351-400351IAGILIVLSS361VACSLGVFSY371IGLPLTLIVI381EVIPFLVLAV391GVDNIFILVQ
401-450401AYQRDERLQG411ETLDQQLGRV421LGEVAPSMFL431SSFSETVAFF441LGALSVMPAV
451-500451HTFSLFAGLA461VFIDFLLQIT471CFVSLLGLDI481KRQEKNRLDI491FCCVRGAEDG
501-550501TSVQASESCL511FRFFKNSYSP521LLLKDWMRPI531VIAIFVGVLS541FSIAVLNKVD
551-600551IGLDQSLSMP561DDSYMVDYFK571SISQYLHAGP581PVYFVLEEGH591DYTSSKGQNM
601-650601VCGGMGCNND611SLVQQIFNAA621QLDNYTRIGF631APSSWIDDYF641DWVKPQSSCC
651-700651RVDNITDQFC661NASVVDPACV671RCRPLTPEGK681QRPQGGDFMR691FLPMFLSDNP
701-750701NPKCGKGGHA711AYSSAVNILL721GHGTRVGATY731FMTYHTVLQT741SADFIDALKK
751-800751ARLIASNVTE761TMGINGSAYR771VFPYSVFYVF781YEQYLTIIDD791TIFNLGVSLG
801-850801AIFLVTMVLL811GCELWSAVIM821CATIAMVLVN831MFGVMWLWGI841SLNAVSLVNL
851-900851VMSCGISVEF861CSHITRAFTV871SMKGSRVERA881EEALAHMGSS891VFSGITLTKF
901-950901GGIVVLAFAK911SQIFQIFYFR921MYLAMVLLGA931THGLIFLPVL941LSYIGPSVNK
951-971951AKSCATEERY961KGTERERLLN971F
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 36 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.71
|
|
| 84 | - | - | - |
Deep-Palm: 0.90
|
|
| 85 | - | - | - |
Deep-Palm: 0.92
|
|
| 95 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.94
Deep-Palm: 0.82
|
|
| 107 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.57
|
|
| 113 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.21
|
|
| 125 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.61
|
|
| 229 | - | - | - |
Deep-Palm: 0.17
|
|
| 240 | - | - | - |
Deep-Palm: 0.18
|
|
| 277 | - | - | - |
Deep-Palm: 0.03
|
|
| 338 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 363 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.98
|
|
| 471 | - | - | - |
Deep-Palm: 0.80
|
|
| 492 | SWISSPALM DBPTM CYSMODDB | Sterol-sensing domain of SREBP cleavage-activation | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.93
|
| 493 | SWISSPALM DBPTM CYSMODDB | Sterol-sensing domain of SREBP cleavage-activation | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.92
|
| 509 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.86
Deep-Palm: 0.97
|
|
| 602 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.10
|
|
| 607 | - | - | - |
Deep-Palm: 0.16
|
|
| 649 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.73
Deep-Palm: 0.06
|
|
| 650 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.67
Deep-Palm: 0.06
|
|
| 660 | - | - | - |
Deep-Palm: 0.17
|
|
| 669 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.39
|
|
| 672 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.63
|
|
| 704 | - | - | - |
Deep-Palm: 0.50
|
|
| 812 | - | - | - |
Deep-Palm: 0.75
|
|
| 821 | - | - | - |
Deep-Palm: 0.05
|
|
| 854 | - | - | - |
Deep-Palm: 0.23
|
|
| 861 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.11
|
|
| 954 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
2
LNCaP cells (Mass)
Specificity: 0.133
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 146 | Y → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 346 | C → C | 0.002506 | SNP | Silent | COAD |
| 570 | Y → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 714 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 763 | F → Cfs*8 | 0.002506 | DEL | Frame Shift Del | COAD |
| 799 | C → Lfs*7 | 0.002506 | INS | Frame Shift Ins | COAD |
| 909 | C → C | 0.001014 | SNP | Silent | BRCA |
| 909 | C → C | 0.002288 | SNP | Silent | STAD |
| 998 | F → C | 0.002294 | SNP | Missense Mutation | OV |
| 1146 | G → C | 0.006993 | SNP | Missense Mutation | LAML |
| 799* | C → ? | 0.005618 | SNP | Nonsense Mutation | PAAD |