Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| K7ESG8 | ACLY | ATP citrate lyase | Homo sapiens (Human) | 109 aa |
Protein Details: K7ESG8 (ACLY)
Protein Information
| Accession | K7ESG8 |
|---|---|
| Protein Names | ATP citrate lyase |
| Gene Symbol | ACLY |
| Organism | Homo sapiens (Human) |
| Length | 109 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSAKAISEQT11GKELLYKFIC21TTSAIQNRFK31YARVTPDTDW41ARLLQDHPWL
51-10051LSQNLVVKPD61QLIKRRGKLG71LVGVNLTLDG81VKSWLKPRLG91QEATVGKATG
101-109101FLKNFLIEP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 20 | SWISSPALM DBPTM CYSMODDB | ATP-citrate synthase ATP-grasp domain | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.86
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
3
PC3
Specificity: 0.333
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.333
3/3 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | C → C | 0.002288 | SNP | Silent | STAD |
| 184 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 576 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 653 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 728 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 887 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 893 | C → Y | 0.002747 | SNP | Missense Mutation | LIHC |
| 1033 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |