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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
K7ESM5 TUBB6 Tubulin beta chain Homo sapiens (Human) 338 aa

Protein Details: K7ESM5 (TUBB6)

Protein Information
AccessionK7ESM5
Protein NamesTubulin beta chain
Gene SymbolTUBB6
OrganismHomo sapiens (Human)
Length338 aa
IsoformsNo isoforms
Related PMIDs 31251020
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MREIVHIQAG11QCGNQIGTKF21WEVISDEHGI31DPAGGYVGDS41ALQLERINVY
51-10051YNESSCQTGA61GNNWAKGHYT71EGAELVDAVL81DVVRKECEHC91DCLQGFQLTH
101-150101SLGGGTGSGM111GTLLISKIRE121EFPDRIMNTF131SVMPSPKVSD141TVVEPYNATL
151-200151SVHQLVENTD161ETYCIDNEAL171YDICFRTLKL181TTPTYGDLNH191LVSATMSGVT
201-250201TSLRFPGQLN211ADLRKLAVNM221VPFPRLHFFM231PGFAPLTSRG241SQQYRALTVP
251-300251ELTQQMFDAR261NMMAACDPRH271GRYLTVATVF281RGPMSMKEVD291EQMLAIQSKN
301-338301SSYFVEWIPN311NVKVAVCDIP321PRGLKMASTF331IGNSTAIQ
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
12 Tubulin/FtsZ, GTPase domain superfamily OS01G0282866 PROTEIN - -
Deep-Palm: 0.03
56 - - -
Deep-Palm: 0.23
87 - - -
Deep-Palm: 0.67
90 - - -
Deep-Palm: 0.65
92 - - -
Deep-Palm: 0.79
164 - - -
Deep-Palm: 0.13
174 - - -
GPS-Palm: 0.79
Deep-Palm: 0.16
266 SWISSPALM DBPTM CYSMODDB Tubulin C-terminal domain - -
GPS-Palm: 0.94
Deep-Palm: 0.70
317 - - -
GPS-Palm: 0.92
Deep-Palm: 0.81
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
146 G → C 0.001764 SNP Missense Mutation LUAD
153 S → C 0.002033 SNP Missense Mutation LUSC
201 C → S 0.001764 SNP Missense Mutation LUAD
241 R → C 0.002033 SNP Missense Mutation LUSC
244 G → C 0.002506 SNP Missense Mutation COAD
251 R → C 0.002506 SNP Missense Mutation COAD
303 C → C 0.001887 SNP Silent UCEC
318 R → C 0.002141 SNP Missense Mutation SKCM