Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| M0QXM4 | SLC1A5 | Amino acid transporter | Homo sapiens (Human) | 365 aa |
Protein Details: M0QXM4 (SLC1A5)
Protein Information
| Accession | M0QXM4 |
|---|---|
| Protein Names | Amino acid transporter |
| Gene Symbol | SLC1A5 |
| Organism | Homo sapiens (Human) |
| Length | 365 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29575903 31251020 32651440 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVSNNPLCVC11LCRNIFPSNL21VSAAFRSYST31TYEERNITGT41RVKVPVGQEV
51-10051EGMNILGLVV61FAIVFGVALR71KLGPEGELLI81RFFNSFNEAT91MVLVSWIMWY
101-150101APVGIMFLVA111GKIVEMEDVG121LLFARLGKYI131LCCLLGHAIH141GLLVLPLIYF
151-200151LFTRKNPYRF161LWGIVTPLAT171AFGTSSSSAT181LPLMMKCVEE191NNGVAKHISR
201-250201FILPIGATVN211MDGAALFQCV221AAVFIAQLSQ231QSLDFVKIIT241ILVTATASSV
251-300251GAAGIPAGGV261LTLAIILEAV271NLPVDHISLI281LAVDWLVDRS291CTVLNVEGDA
301-350301LGAGLLQNYV311DRTESRSTEP321ELIQVKSELP331LDPLPVPTEE341GNPLLKHYRG
351-365351PAGDATVASE361KESVM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.02
|
|
| 10 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.02
|
|
| 12 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.04
|
|
| 132 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.96
|
|
| 133 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 187 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.70
|
|
| 219 | - | - | - |
Deep-Palm: 0.64
|
|
| 291 | SWISSPALM DBPTM CYSMODDB | Sodium:dicarboxylate symporter family |
HeLa
(29575903)
|
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.67
Deep-Palm: 0.92
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
LNCaP
Specificity: 0.333
3/3 (100.0%)
2
HeLa cell
Specificity: 0.222
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.111
1/1 (100.0%)
1
DU145 cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP cells (Mass)
Specificity: 0.222
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 202 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 305 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 330 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 395 | C → C | 0.004577 | SNP | Silent | STAD |
| 405 | S → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 467 | C → _V469delinsF | 0.002976 | DEL | In Frame Del | KIRC |