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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
M0QY43 MYH14 Myosin heavy chain 14 Homo sapiens (Human) 1002 aa

Protein Details: M0QY43 (MYH14)

Protein Information
AccessionM0QY43
Protein NamesMyosin heavy chain 14
Gene SymbolMYH14
OrganismHomo sapiens (Human)
Length1002 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAVTMSVPG11RKAPPRPGPV21PEAAQPFLFT31PRGPSAGGGP41GSGTSPQVEW
51-10051TARRLVWVPS61ELHGFEAAAL71RDEGEEEAEV81ELAESGRRLR91LPRDQIQRMN
101-150101PPKFSKAEDM111AELTCLNEAS121VLHNLRERYY131SGLIYTYSGL141FCVVINPYKQ
151-200151LPIYTEAIVE161MYRGKKRHEV171PPHVYAVTEG181AYRSMLQDRE191DQSILCTGES
201-250201GAGKTENTKK211VIQYLAHVAS221SPKGRKEPGV231PASVSTVSYG241ELERQLLQAN
251-300251PILEAFGNAK261TVKNDNSSRF271GKFIRINFDV281AGYIVGANIE291TYLLEKSRAI
301-350301RQAKDECSFH311IFYQLLGGAG321EQLKADLLLE331PCSHYRFLTN341GPSSSPGQER
351-400351ELFQETLESL361RVLGFSHEEI371ISMLRMVSAV381LQFGNIALKR391ERNTDQATMP
401-450401DNTAAQKLCR411LLGLGVTDFS421RALLTPRIKV431GRDYVQKAQT441KEQADFALEA
451-500451LAKATYERLF461RWLVLRLNRA471LDRSPRQGAS481FLGILDIAGF491EIFQLNSFEQ
501-550501LCINYTNEKL511QQLFNHTMFV521LEQEEYQREG531IPWTFLDFGL541DLQPCIDLIE
551-600551RPANPPGLLA561LLDEECWFPK571ATDKSFVEKV581AQEQGGHPKF591QRPRHLRDQA
601-650601DFSVLHYAGK611VDYKANEWLM621KNMDPLNDNV631AALLHQSTDR641LTAEIWKDVE
651-700651GIVGLEQVSS661LGDGPPGGRP671RRGMFRTVGQ681LYKESLSRLM691ATLSNTNPSF
701-750701VRCIVPNHEK711RAGKLEPRLV721LDQLRCNGVL731EGIRICRQGF741PNRILFQEFR
751-800751QRYEILTPNA761IPKGFMDGKQ771ACEKMIQALE781LDPNLYRVGQ791SKIFFRAGVL
801-850801AQLEEERDLK811VTDIIVSFQA821AARGYLARRA831FQKRQQQQSA841LRVMQRNCAA
851-900851YLKLRHWQWW861RLFTKVKPLL871QVTRQDEVLQ881ARAQELQKVQ891ELQQQSAREV
901-950901GELQGRVAQL911EEERARLAEQ921LRAEAELCAE931AEETRGRLAA941RKQELELVVS
951-1000951ELEARVGEEE961ECSRQMQTEK971KRLQQHIQEL981EAHLEAEEGA991RQKLQLEKVT
1001-10021001TE
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
115 - - -
GPS-Palm: 0.73
Deep-Palm: 0.85
142 - - -
Deep-Palm: 0.22
196 SWISSPALM DBPTM CYSMODDB Myosin head (motor domain)
HeLa (29575903)
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.79
Deep-Palm: 0.88
307 - - -
Deep-Palm: 0.93
332 - - -
GPS-Palm: 0.88
Deep-Palm: 0.94
409 - - -
GPS-Palm: 0.86
Deep-Palm: 0.98
502 - - -
GPS-Palm: 0.86
Deep-Palm: 0.10
545 - - -
Deep-Palm: 0.91
566 - - -
GPS-Palm: 0.82
Deep-Palm: 0.98
703 - - -
Deep-Palm: 0.88
726 - -
LNCaP (31251020)
GPS-Palm: 0.72
Deep-Palm: 0.97
736 - - -
GPS-Palm: 0.85
Deep-Palm: 0.94
772 - - -
GPS-Palm: 0.81
Deep-Palm: 0.84
848 - - -
GPS-Palm: 0.92
Deep-Palm: 0.32
928 - - -
Deep-Palm: 0.98
962 - - -
Deep-Palm: 0.87
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
LNCaP
Specificity: 0.300
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.300
3/3 (100.0%)
1
PC3
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.300
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
28 L → Cfs*72 0.002976 DEL Frame Shift Del KIRC
54 R → C 0.002288 SNP Missense Mutation STAD
54 R → C 0.002506 SNP Missense Mutation COAD
154 Y → C 0.001969 SNP Missense Mutation LGG
167 R → C 0.005435 SNP Missense Mutation ESCA
196 C → C 0.001887 SNP Splice Region UCEC
267 R → C 0.002141 SNP Missense Mutation SKCM
450 R → C 0.001887 SNP Missense Mutation UCEC
458 R → C 0.002288 SNP Missense Mutation STAD
520 R → C 0.001014 SNP Missense Mutation BRCA
559 W → C 0.002033 SNP Missense Mutation LUSC
717 R → C 0.001887 SNP Missense Mutation UCEC
820 R → C 0.002141 SNP Missense Mutation SKCM
826 R → C 0.001887 SNP Missense Mutation UCEC
933 R → C 0.002506 SNP Missense Mutation COAD
956 R → C 0.001014 SNP Missense Mutation BRCA
1024 R → C 0.004283 SNP Missense Mutation SKCM
1059 R → C 0.002506 SNP Missense Mutation COAD
1237 G → C 0.001887 SNP Missense Mutation UCEC
1267 G → C 0.002033 SNP Missense Mutation LUSC
1273 R → C 0.001887 SNP Missense Mutation UCEC
1412 R → C 0.001969 SNP Missense Mutation LGG
1581 R → C 0.001887 SNP Missense Mutation UCEC
1581 R → C 0.005618 SNP Missense Mutation PAAD
1629 R → C 0.002747 SNP Missense Mutation LIHC
1665 R → C 0.002288 SNP Missense Mutation STAD
1665 R → C 0.002545 SNP Missense Mutation GBM
1665 R → C 0.002141 SNP Missense Mutation SKCM
1749 R → C 0.002033 SNP Missense Mutation LUSC
1754 R → C 0.002506 SNP Missense Mutation COAD
1775 R → C 0.002506 SNP Missense Mutation COAD
1794 R → C 0.001014 SNP Missense Mutation BRCA
1794 R → C 0.002288 SNP Missense Mutation STAD
1826 R → C 0.002294 SNP Missense Mutation OV
1854 R → C 0.001887 SNP Missense Mutation UCEC
1936 R → C 0.001887 SNP Missense Mutation UCEC
1947 R → C 0.002288 SNP Missense Mutation STAD