Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
M0R116 ATP1A3 Sodium/potassium-transporting ATPase subunit alpha Homo sapiens (Human) 983 aa

Protein Details: M0R116 (ATP1A3)

Protein Information
AccessionM0R116
Protein NamesSodium/potassium-transporting ATPase subunit alpha
Gene SymbolATP1A3
OrganismHomo sapiens (Human)
Length983 aa
IsoformsNo isoforms
Related PMIDs 19137006 26876311 29575903 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MTEHKMSVEE11VCRKYNTDCV21QGLTHSKAQE31ILARDGPNAL41TPPPTTPEWV
51-10051KFCRQLFGGF61SILLWIGAIL71CFLAYGIQAG81TEDDPSGDNL91YLGIVLAAVV
101-150101IITGCFSYYQ111EAKSSKIMES121FKNMVPQQAL131VIREGEKMQV141NAEEVVVGDL
151-200151VEIKGGDRVP161ADLRIISAHG171CKVDNSSLTG181ESEPQTRSPD191CTHDNPLETR
201-250201NITFFSTNCV211EGTARGVVVA221TGDRTVMGRI231ATLASGLEVG241KTPIAIEIEH
251-300251FIQLITGVAV261FLGVSFFILS271LILGYTWLEA281VIFLIGIIVA291NVPEGLLATV
301-350301TVCLTLTAKR311MARKNCLVKN321LEAVETLGST331STICSDKTGT341LTQNRMTVAH
351-400351MWFDNQIHEA361DTTEDQSGTS371FDKSSHTWVA381LSHIAGLCNR391AVFKGGQDNI
401-450401PVLKRDVAGD411ASESALLKCI421ELSSGSVKLM431RERNKKVAEI441PFNSTNKYQL
451-500451SIHETEDPND461NRYLLVMKGA471PERILDRCST481ILLQGKEQPL491DEEMKEAFQN
501-550501AYLELGGLGE511RVLGFCHYYL521PEEQFPKGFA531FDCDDVNFTT541DNLCFVGLMS
551-600551MIDPPRAAVP561DAVGKCRSAG571IKVIMVTGDH581PITAKAIAKG591VGIISEGNET
601-650601VEDIAARLNI611PVSQVNPRDA621KACVIHGTDL631KDFTSEQIDE641ILQNHTEIVF
651-700651ARTSPQQKLI661IVEGCQRQGA671IVAVTGDGVN681DSPALKKADI691GVAMGIAGSD
701-750701VSKQAADMIL711LDDNFASIVT721GVEEGRLIFD731NLKKSIAYTL741TSNIPEITPF
751-800751LLFIMANIPL761PLGTITILCI771DLGTDMVPAI781SLAYEAAESD791IMKRQPRNPR
801-850801TDKLVNERLI811SMAYGQIGMI821QALGGFFSYF831VILAENGFLP841GNLVGIRLNW
851-900851DDRTVNDLED861SYGQQWTYEQ871RKVVEFTCHT881AFFVSIVVVQ891WADLIICKTR
901-950901RNSVFQQGMK911NKILIFGLFE921ETALAAFLSY931CPGMDVALRM941YPLKPSWWFC
951-983951AFPYSFLIFV961YDEIRKLILR971RNPGGWVEKE981TYY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
12 Cation-transporting P-type ATPase, N-terminal P-type ATPase, transmembrane domain superfamily -
cerebral cortex (36430497)
Deep-Palm: 0.03
19 Cation transport ATPase (P-type) P-type ATPase, transmembrane domain superfamily Cation-transporting P-type ATPase, N-terminal -
cerebral cortex (36430497)
Deep-Palm: 0.77
53 - - -
GPS-Palm: 0.77
Deep-Palm: 0.88
71 - - -
Deep-Palm: 0.80
105 - - -
GPS-Palm: 0.81
Deep-Palm: 0.91
171 - - -
GPS-Palm: 0.73
Deep-Palm: 0.96
191 - -
cerebral cortex (36430497)
Deep-Palm: 0.40
209 - -
cerebral cortex (36430497)
Deep-Palm: 0.95
303 - - -
GPS-Palm: 0.88
Deep-Palm: 0.97
316 - - -
GPS-Palm: 0.93
Deep-Palm: 0.96
334 - -
LNCaP (31251020)
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.76
Deep-Palm: 0.98
388 - -
cerebral cortex (36430497)
GPS-Palm: 0.81
Deep-Palm: 0.88
419 - -
cerebral cortex (36430497)
Deep-Palm: 0.98
478 - -
cerebral cortex (36430497)
GPS-Palm: 0.80
Deep-Palm: 0.98
516 - -
cerebral cortex (36430497)
GPS-Palm: 0.75
Deep-Palm: 0.97
533 - - -
Deep-Palm: 0.14
544 - - -
Deep-Palm: 0.10
566 - - -
GPS-Palm: 0.86
Deep-Palm: 0.95
623 - -
cerebral cortex (36430497)
GPS-Palm: 0.74
Deep-Palm: 0.83
665 SWISSPALM DBPTM CYSMODDB - -
LNCaP (31251020)
cerebral cortex (36430497)
GPS-Palm: 0.95
Deep-Palm: 0.90
769 - - -
Deep-Palm: 0.95
878 - - -
Deep-Palm: 0.06
897 - - -
GPS-Palm: 0.92
Deep-Palm: 0.52
931 - - -
GPS-Palm: 0.84
Deep-Palm: 0.96
950 - - -
Deep-Palm: 0.30
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
1
HeLa cell
Specificity: 0.091
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.091
1/1 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
19 R → C 0.007299 SNP Missense Mutation READ
19 R → C 0.003460 SNP Missense Mutation CESC
185 G → C 0.004219 SNP Missense Mutation SARC
217 R → C 0.002506 SNP Missense Mutation COAD
259 R → C 0.002141 SNP Missense Mutation SKCM
340 R → C 0.002545 SNP Missense Mutation GBM
346 C → C 0.001887 SNP Silent UCEC
346 C → S 0.006993 SNP Missense Mutation LAML
375 R → C 0.001887 SNP Missense Mutation UCEC
420 R → C 0.002288 SNP Missense Mutation STAD
420 R → C 0.001887 SNP Missense Mutation UCEC
461 R → C 0.002427 SNP Missense Mutation BLCA
463 R → C 0.027027 SNP Missense Mutation DLBC
478 Y → C 0.001887 SNP Missense Mutation UCEC
541 R → C 0.002506 SNP Missense Mutation COAD
546 C → S 0.002545 SNP Missense Mutation GBM
682 R → C 0.001887 SNP Missense Mutation UCEC
756 R → C 0.002506 SNP Missense Mutation COAD
793 G → C 0.001014 SNP Missense Mutation BRCA
803 G → C 0.005435 SNP Missense Mutation ESCA
980 C → Vfs*136 0.002294 DEL Frame Shift Del OV
995 R → C 0.001014 SNP Missense Mutation BRCA
995 R → C 0.001969 SNP Missense Mutation HNSC
1000 R → C 0.001887 SNP Missense Mutation UCEC