Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| M0R1A7 | RPL18A | 60S ribosomal protein L18a | Homo sapiens (Human) | 147 aa |
Protein Details: M0R1A7 (RPL18A)
Protein Information
| Accession | M0R1A7 |
|---|---|
| Protein Names | 60S ribosomal protein L18a |
| Gene Symbol | RPL18A |
| Organism | Homo sapiens (Human) |
| Length | 147 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRIFAPNHVV11AKSRFWYFVS21QLKKMKKSSG31EIVYCGQVFE41KSPLRVKNFG
51-10051IWLRYDSRSG61THNMYREYRD71LTTAGAVTQC81YRDMGARHRA91RAHSIQIMKV
101-147101EEIAASKCRR111PAVKQFHDSK121IKFPLPHRVL131RRQHKPRFTT141KRPNTFF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 35 | Large ribosomal subunit protein eL20, eukaryotes | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.94
|
|
| 80 | SWISSPALM DBPTM CYSMODDB | Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.96
Deep-Palm: 0.91
|
| 108 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.48
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.222
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.444
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.111
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 29 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 43 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 63 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 83 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 83 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 166 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 109* | C → ? | 0.005618 | SNP | Nonsense Mutation | PAAD |