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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
M0R2D3 TUBB4A Tubulin beta 4A class IVa Homo sapiens (Human) 340 aa

Protein Details: M0R2D3 (TUBB4A)

Protein Information
AccessionM0R2D3
Protein NamesTubulin beta 4A class IVa
Gene SymbolTUBB4A
OrganismHomo sapiens (Human)
Length340 aa
IsoformsNo isoforms
Related PMIDs 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MREIVHLQAG11QCGNQIGAKF21WEVISDEHGI31DPTGTYHGDS41DLQLERINVY
51-10051YNEEFPDRIM61NTFSVVPSPK71VSDTVVEPYN81ATLSVHQLVE91NTDETYCIDN
101-150101EALYDICFRT111LKLTTPTYGD121LNHLVSATMS131GVTTCLRFPG141QLNADLRKLA
151-200151VNMVPFPRLH161FFMPGFAPLT171SRGSQQYRAL181TVPELTQQMF191DAKNMMAACD
201-250201PRHGRYLTVA211AVFRGRMSMK221EVDEQMLSVQ231SKNSSYFVEW241IPNNVKTAVC
251-300251DIPPRGLKMA261ATFIGNSTAI271QELFKRISEQ281FTAMFRRKAF291LHWYTGEGMD
301-340301EMEFTEAESN311MNDLVSEYQQ321YQDATAEEGE331FEEEAEEEVA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
12 Tubulin/FtsZ, GTPase domain superfamily OS01G0282866 PROTEIN - -
GPS-Palm: 0.65
Deep-Palm: 0.06
97 - - -
Deep-Palm: 0.13
107 - - -
GPS-Palm: 0.79
Deep-Palm: 0.16
135 SWISSPALM DBPTM CYSMODDB - -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.90
Deep-Palm: 0.97
199 - -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.94
Deep-Palm: 0.68
250 - -
cerebral cortex (36430497)
GPS-Palm: 0.92
Deep-Palm: 0.74
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
1
cerebral cortex
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
77 R → C 0.002141 SNP Missense Mutation SKCM
127 C → C 0.001887 SNP Silent UCEC
156 R → C 0.002020 SNP Missense Mutation PRAD
162 R → C 0.002506 SNP Missense Mutation COAD
183 Y → C 0.002033 SNP Missense Mutation LUSC
213 R → C 0.001969 SNP Missense Mutation HNSC
251 R → C 0.002506 SNP Missense Mutation COAD
251 R → C 0.001969 SNP Missense Mutation LGG
262 R → C 0.002288 SNP Missense Mutation STAD
303 C → C 0.002545 SNP Silent GBM
309 R → C 0.002545 SNP Missense Mutation GBM
309 R → C 0.001887 SNP Missense Mutation UCEC
354 C → C 0.002506 SNP Silent COAD
354 C → C 0.003774 SNP Silent UCEC
380 R → C 0.001887 SNP Missense Mutation UCEC
391 R → C 0.002020 SNP Missense Mutation PRAD
391 R → C 0.002294 SNP Missense Mutation OV