Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00116 | AGPS | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) … | Homo sapiens (Human) | 658 aa |
Protein Details: O00116 (AGPS)
Protein Information
| Accession | O00116 |
|---|---|
| Protein Names | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) |
| Gene Symbol | AGPS |
| Organism | Homo sapiens (Human) |
| Length | 658 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEAAAAAGG11TGLGAGASYG21SAADRDRDPD31PDRAGRRLRV41LSGHLLGRPR
51-10051EALSTNECKA61RRAASAATAA71PTATPAAQES81GTIPKKRQEV91MKWNGWGYND
101-150101SKFIFNKKGQ111IELTGKRYPL121SGMGLPTFKE131WIQNTLGVNV141EHKTTSKASL
151-200151NPSDTPPSVV161NEDFLHDLKE171TNISYSQEAD181DRVFRAHGHC191LHEIFLLREG
201-250201MFERIPDIVL211WPTCHDDVVK221IVNLACKYNL231CIIPIGGGTS241VSYGLMCPAD
251-300251ETRTIISLDT261SQMNRILWVD271ENNLTAHVEA281GITGQELERQ291LKESGYCTGH
301-350301EPDSLEFSTV311GGWVSTRASG321MKKNIYGNIE331DLVVHIKMVT341PRGIIEKSCQ
351-400351GPRMSTGPDI361HHFIMGSEGT371LGVITEATIK381IRPVPEYQKY391GSVAFPNFEQ
401-450401GVACLREIAK411QRCAPASIRL421MDNKQFQFGH431ALKPQVSSIF441TSFLDGLKKF
451-500451YITKFKGFDP461NQLSVATLLF471EGDREKVLQH481EKQVYDIAAK491FGGLAAGEDN
501-550501GQRGYLLTYV511IAYIRDLALE521YYVLGESFET531SAPWDRVVDL541CRNVKERITR
551-600551ECKEKGVQFA561PFSTCRVTQT571YDAGACIYFY581FAFNYRGISD591PLTVFEQTEA
601-650601AAREEILANG611GSLSHHHGVG621KLRKQWLKES631ISDVGFGMLK641SVKEYVDPNN
651-658651IFGNRNLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 58 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 190 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.85
|
|
| 214 | - | - | - |
Deep-Palm: 0.61
|
|
| 226 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.30
|
|
| 231 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
|
| 247 | - | - | - |
Deep-Palm: 0.96
|
|
| 297 | - | - | - |
Deep-Palm: 0.96
|
|
| 349 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.24
|
|
| 404 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.95
|
|
| 413 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.85
|
|
| 541 | - | - | - |
Deep-Palm: 0.91
|
|
| 552 | - | - | - |
Deep-Palm: 0.84
|
|
| 565 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.41
|
|
| 576 | - | - | - |
Deep-Palm: 0.11
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
2
PC3
Specificity: 0.250
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 58 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 317 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 474 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 474 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 491 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 565 | C → C | 0.001764 | SNP | Splice Region | LUAD |
| 608 | A → Cfs*2 | 0.001887 | INS | Frame Shift Ins | UCEC |
| 632 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |