Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00180 | KCNK1 | Potassium channel subfamily K member … | Homo sapiens (Human) | 336 aa |
Protein Details: O00180 (KCNK1)
Protein Information
| Accession | O00180 |
|---|---|
| Protein Names | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1) |
| Gene Symbol | KCNK1 |
| Organism | Homo sapiens (Human) |
| Length | 336 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLQSLAGSSC11VRLVERHRSA21WCFGFLVLGY31LLYLVFGAVV41FSSVELPYED
51-10051LLRQELRKLK61RRFLEEHECL71SEQQLEQFLG81RVLEASNYGV91SVLSNASGNW
101-150101NWDFTSALFF111ASTVLSTTGY121GHTVPLSDGG131KAFCIIYSVI141GIPFTLLFLT
151-200151AVVQRITVHV161TRRPVLYFHI171RWGFSKQVVA181IVHAVLLGFV191TVSCFFFIPA
201-250201AVFSVLEDDW211NFLESFYFCF221ISLSTIGLGD231YVPGEGYNQK241FRELYKIGIT
251-300251CYLLLGLIAM261LVVLETFCEL271HELKKFRKMF281YVKKDKDEDQ291VHIIEHDQLS
301-336301FSSITDQAAG311MKEDQKQNEP321FVATQSSACV331DGPANH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.94
Deep-Palm: 0.07
|
| 22 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.92
|
|
| 69 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.98
|
|
| 134 | - | - | - |
Deep-Palm: 0.71
|
|
| 194 | - | - | - |
Deep-Palm: 0.51
|
|
| 219 | - | - | - |
Deep-Palm: 0.16
|
|
| 251 | - | - | - |
Deep-Palm: 0.93
|
|
| 268 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 329 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 0.500
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP cells (Mass)
Specificity: 0.500
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 134 | C → C | 0.002288 | SNP | Silent | STAD |
| 134 | C → C | 0.001887 | SNP | Silent | UCEC |
| 162 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 171 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 171 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 251 | C → C | 0.001969 | SNP | Splice Region | HNSC |
| 251 | C → Y | 0.002141 | SNP | Missense Mutation | SKCM |
| 329 | C → C | 0.007299 | SNP | Silent | READ |
| 329 | C → C | 0.002141 | SNP | Silent | SKCM |