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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O00180 KCNK1; HOHO1; KCNO1; TWIK1 Potassium channel subfamily K member … Homo sapiens (Human) 336 aa

Protein Details: O00180 (KCNK1)

Protein Information
Accession O00180
Protein Names Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)
Gene Symbol KCNK1; HOHO1; KCNO1; TWIK1
Organism Homo sapiens (Human)
Length 336 aa
Isoforms No isoforms
Related PMIDs 19801377 29575903 31251020
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 1.000
26/46 (56.5%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLQSLAGSSC11VRLVERHRSA21WCFGFLVLGY31LLYLVFGAVV41FSSVELPYED
51-10051LLRQELRKLK61RRFLEEHECL71SEQQLEQFLG81RVLEASNYGV91SVLSNASGNW
101-150101NWDFTSALFF111ASTVLSTTGY121GHTVPLSDGG131KAFCIIYSVI141GIPFTLLFLT
151-200151AVVQRITVHV161TRRPVLYFHI171RWGFSKQVVA181IVHAVLLGFV191TVSCFFFIPA
201-250201AVFSVLEDDW211NFLESFYFCF221ISLSTIGLGD231YVPGEGYNQK241FRELYKIGIT
251-300251CYLLLGLIAM261LVVLETFCEL271HELKKFRKMF281YVKKDKDEDQ291VHIIEHDQLS
301-336301FSSITDQAAG311MKEDQKQNEP321FVATQSSACV331DGPANH
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
10 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 29575903, 19801377
22 Prediction (Low) - -
268 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
134 C → C 0.002288 SNP Silent STAD
134 C → C 0.001887 SNP Silent UCEC
162 R → C 0.002506 SNP Missense Mutation COAD
171 R → C 0.007299 SNP Missense Mutation READ
171 R → C 0.002141 SNP Missense Mutation SKCM
251 C → C 0.001969 SNP Splice Region HNSC
251 C → Y 0.002141 SNP Missense Mutation SKCM
329 C → C 0.007299 SNP Silent READ
329 C → C 0.002141 SNP Silent SKCM