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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O00220 TNFRSF10A; APO2; DR4; TRAILR1 Tumor necrosis factor receptor superfamily … Homo sapiens (Human) 468 aa

Protein Details: O00220 (TNFRSF10A)

Protein Information
Accession O00220
Protein Names Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
Gene Symbol TNFRSF10A; APO2; DR4; TRAILR1
Organism Homo sapiens (Human)
Length 468 aa
Isoforms No isoforms
Related PMIDs 19801377 29575903 31251020
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.897
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.897
26/46 (56.5%)
2
DU145 cells
Specificity: 0.069
2/2 (100.0%)
1
HeLa cells
Specificity: 0.034
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPPPARVHL11GAFLAVTPNP21GSAASGTEAA31AATPSKVWGS41SAGRIEPRGG
51-10051GRGALPTSMG61QHGPSARARA71GRAPGPRPAR81EASPRLRVHK91TFKFVVVGVL
101-150101LQVVPSSAAT111IKLHDQSIGT121QQWEHSPLGE131LCPPGSHRSE141HPGACNRCTE
151-200151GVGYTNASNN161LFACLPCTAC171KSDEEERSPC181TTTRNTACQC191KPGTFRNDNS
201-250201AEMCRKCSRG211CPRGMVKVKD221CTPWSDIECV231HKESGNGHNI241WVILVVTLVV
251-300251PLLLVAVLIV261CCCIGSGCGG271DPKCMDRVCF281WRLGLLRGPG291AEDNAHNEIL
301-350301SNADSLSTFV311SEQQMESQEP321ADLTGVTVQS331PGEAQCLLGP341AEAEGSQRRR
351-400351LLVPANGADP361TETLMLFFDK371FANIVPFDSW381DQLMRQLDLT391KNEIDVVRAG
401-450401TAGPGDALYA411MLMKWVNKTG421RNASIHTLLD431ALERMEERHA441REKIQDLLVD
451-468451SGKFIYLEDG461TGSAVSLE
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
167 Prediction (Low) - -
188 Prediction (Medium) - -
190 Prediction (Low) - -
211 Prediction (Medium) - -
261 DBPTM SWISSPALM Prediction (High) - -
262 DBPTM SWISSPALM Prediction (High) - -
263 DBPTM SWISSPALM Prediction (High) - -
268 Prediction (Medium) - -
274 Prediction (Low) - -
279 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
132 C → F 0.002294 SNP Missense Mutation OV
136 S → C 0.002545 SNP Missense Mutation GBM
164 C → Y 0.001887 SNP Missense Mutation UCEC
180 C → Afs*63 0.002545 DEL Frame Shift Del GBM
190 C → W 0.002294 SNP Missense Mutation OV
267 G → C 0.002506 SNP Missense Mutation COAD