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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O00220 TNFRSF10A Tumor necrosis factor receptor superfamily … Homo sapiens (Human) 468 aa

Protein Details: O00220 (TNFRSF10A)

Protein Information
AccessionO00220
Protein NamesTumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
Gene SymbolTNFRSF10A
OrganismHomo sapiens (Human)
Length468 aa
IsoformsNo isoforms
Related PMIDs 31251020
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPPPARVHL11GAFLAVTPNP21GSAASGTEAA31AATPSKVWGS41SAGRIEPRGG
51-10051GRGALPTSMG61QHGPSARARA71GRAPGPRPAR81EASPRLRVHK91TFKFVVVGVL
101-150101LQVVPSSAAT111IKLHDQSIGT121QQWEHSPLGE131LCPPGSHRSE141HPGACNRCTE
151-200151GVGYTNASNN161LFACLPCTAC171KSDEEERSPC181TTTRNTACQC191KPGTFRNDNS
201-250201AEMCRKCSRG211CPRGMVKVKD221CTPWSDIECV231HKESGNGHNI241WVILVVTLVV
251-300251PLLLVAVLIV261CCCIGSGCGG271DPKCMDRVCF281WRLGLLRGPG291AEDNAHNEIL
301-350301SNADSLSTFV311SEQQMESQEP321ADLTGVTVQS331PGEAQCLLGP341AEAEGSQRRR
351-400351LLVPANGADP361TETLMLFFDK371FANIVPFDSW381DQLMRQLDLT391KNEIDVVRAG
401-450401TAGPGDALYA411MLMKWVNKTG421RNASIHTLLD431ALERMEERHA441REKIQDLLVD
451-468451SGKFIYLEDG461TGSAVSLE
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
132 - - -
Deep-Palm: 0.62
145 - - -
Deep-Palm: 0.08
148 - - -
Deep-Palm: 0.26
164 - - -
Deep-Palm: 0.74
167 - - -
GPS-Palm: 0.65
Deep-Palm: 0.39
170 - - -
Deep-Palm: 0.36
180 - - -
Deep-Palm: 0.20
188 - - -
GPS-Palm: 0.81
Deep-Palm: 0.17
190 - - -
GPS-Palm: 0.77
Deep-Palm: 0.10
204 - - -
Deep-Palm: 0.19
207 - - -
Deep-Palm: 0.15
211 - - -
GPS-Palm: 0.85
Deep-Palm: 0.07
221 - - -
Deep-Palm: 0.10
229 - - -
Deep-Palm: 0.10
261 DBPTM SWISSPALM - - -
GPS-Palm: 0.93
Deep-Palm: 0.98
262 DBPTM SWISSPALM - - -
GPS-Palm: 0.93
Deep-Palm: 0.98
263 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.98
268 - - -
GPS-Palm: 0.82
Deep-Palm: 0.75
274 - - -
GPS-Palm: 0.70
Deep-Palm: 0.52
279 - - -
GPS-Palm: 0.79
Deep-Palm: 0.93
336 - - -
Deep-Palm: 0.98
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
132 C → F 0.002294 SNP Missense Mutation OV
136 S → C 0.002545 SNP Missense Mutation GBM
164 C → Y 0.001887 SNP Missense Mutation UCEC
180 C → Afs*63 0.002545 DEL Frame Shift Del GBM
190 C → W 0.002294 SNP Missense Mutation OV
267 G → C 0.002506 SNP Missense Mutation COAD