Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit … | Homo sapiens (Human) | 456 aa |
Protein Details: O00232 (PSMD12)
Protein Information
| Accession | O00232 |
|---|---|
| Protein Names | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) |
| Gene Symbol | PSMD12 |
| Organism | Homo sapiens (Human) |
| Length | 456 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADGGSERAD11GRIVKMEVDY21SATVDQRLPE31CAKLAKEGRL41QEVIETLLSL
51-10051EKQTRTASDM61VSTSRILVAV71VKMCYEAKEW81DLLNENIMLL91SKRRSQLKQA
101-150101VAKMVQQCCT111YVEEITDLPI121KLRLIDTLRM131VTEGKIYVEI141ERARLTKTLA
151-200151TIKEQNGDVK161EAASILQELQ171VETYGSMEKK181ERVEFILEQM191RLCLAVKDYI
201-250201RTQIISKKIN211TKFFQEENTE221KLKLKYYNLM231IQLDQHEGSY241LSICKHYRAI
251-300251YDTPCIQAES261EKWQQALKSV271VLYVILAPFD281NEQSDLVHRI291SGDKKLEEIP
301-350301KYKDLLKLFT311TMELMRWSTL321VEDYGMELRK331GSLESPATDV341FGSTEEGEKR
351-400351WKDLKNRVVE361HNIRIMAKYY371TRITMKRMAQ381LLDLSVDESE391AFLSNLVVNK
401-450401TIFAKVDRLA411GIINFQRPKD421PNNLLNDWSQ431KLNSLMSLVN441KTTHLIAKEE
451-456451MIHNLQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 31 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.98
|
|
| 74 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.54
|
|
| 108 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.90
|
|
| 109 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.89
|
|
| 193 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.85
|
|
| 244 | - | - | - |
Deep-Palm: 0.22
|
|
| 255 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.64
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
HAP1 cell
Specificity: 0.667
2/2 (100.0%)
1
293T cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 142 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 227 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 242 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 316 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 342 | G → C | 0.003460 | SNP | Missense Mutation | CESC |