Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00299 | CLIC1 | Chloride intracellular channel protein 1 … | Homo sapiens (Human) | 241 aa |
Protein Details: O00299 (CLIC1)
Protein Information
| Accession | O00299 |
|---|---|
| Protein Names | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) |
| Gene Symbol | CLIC1 |
| Organism | Homo sapiens (Human) |
| Length | 241 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEEQPQVEL11FVKAGSDGAK21IGNCPFSQRL31FMVLWLKGVT41FNVTTVDTKR
51-10051RTETVQKLCP61GGQLPFLLYG71TEVHTDTNKI81EEFLEAVLCP91PRYPKLAALN
101-150101PESNTAGLDI111FAKFSAYIKN121SNPALNDNLE131KGLLKALKVL141DNYLTSPLPE
151-200151EVDETSAEDE161GVSQRKFLDG171NELTLADCNL181LPKLHIVQVV191CKKYRGFTIP
201-241201EAFRGVHRYL211SNAYAREEFA221STCPDDEEIE231LAYEQVAKAL241K
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 24 | SWISSPALM DBPTM CYSMODDB | CLIC, N-terminal domain CLIC-like N-terminal domain Thioredoxin-like superfamily CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED Glutaredoxin |
HeLa
(29575903)
| - |
GPS-Palm: 0.89
Deep-Palm: 0.85
|
| 59 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.98
|
|
| 89 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.95
|
|
| 178 | SWISSPALM DBPTM CYSMODDB | Glutathione S-transferase C-terminal domain |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.73
Deep-Palm: 0.98
|
| 191 | SWISSPALM DBPTM CYSMODDB | Glutathione S-transferase C-terminal domain |
SW480 cell line
(26865113)
HeLa
(29575903)
| - |
GPS-Palm: 0.84
Deep-Palm: 0.90
|
| 223 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.74
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
PC3
Specificity: 0.400
4/4 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.200
2/2 (100.0%)
1
U937 cell
Specificity: 0.100
1/1 (100.0%)
1
293T cell
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | C → F | 0.002427 | SNP | Missense Mutation | BLCA |
| 163 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 223 | C → R | 0.002506 | SNP | Missense Mutation | COAD |