Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00299 | CLIC1; G6; NCC27 | Chloride intracellular channel protein 1 … | Homo sapiens (Human) | 241 aa |
Protein Details: O00299 (CLIC1)
Protein Information
| Accession | O00299 |
|---|---|
| Protein Names | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) |
| Gene Symbol | CLIC1; G6; NCC27 |
| Organism | Homo sapiens (Human) |
| Length | 241 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.521
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.521
25/46 (54.3%)
10
HAP1 cells
Specificity: 0.208
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.083
4/25 (16.0%)
4
PC3 cells
Specificity: 0.083
4/4 (100.0%)
4
293T cells
Specificity: 0.083
4/10 (40.0%)
1
U937 cells
Specificity: 0.021
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAEEQPQVEL11FVKAGSDGAK21IGNCPFSQRL31FMVLWLKGVT41FNVTTVDTKR
51-10051RTETVQKLCP61GGQLPFLLYG71TEVHTDTNKI81EEFLEAVLCP91PRYPKLAALN
101-150101PESNTAGLDI111FAKFSAYIKN121SNPALNDNLE131KGLLKALKVL141DNYLTSPLPE
151-200151EVDETSAEDE161GVSQRKFLDG171NELTLADCNL181LPKLHIVQVV191CKKYRGFTIP
201-241201EAFRGVHRYL211SNAYAREEFA221STCPDDEEIE231LAYEQVAKAL241K
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 24 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | CLIC-like N-terminal domain | 29575903 |
| 59 | Prediction (Medium) | - | - |
| 89 | Prediction (Medium) | - | - |
| 178 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | Glutathione S-transferase C-terminal domain | - |
| 191 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Glutathione S-transferase C-terminal domain | 29575903 |
| 223 | Experimental CYSMODDB SWISSPALM DBPTM | - | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | C → F | 0.002427 | SNP | Missense Mutation | BLCA |
| 163 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 223 | C → R | 0.002506 | SNP | Missense Mutation | COAD |