Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O00461 GOLIM4; GIMPC; GOLPH4; GPP130 Golgi integral membrane protein 4 … Homo sapiens (Human) 696 aa

Protein Details: O00461 (GOLIM4)

Protein Information
Accession O00461
Protein Names Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)
Gene Symbol GOLIM4; GIMPC; GOLPH4; GPP130
Organism Homo sapiens (Human)
Length 696 aa
Isoforms No isoforms
Related PMIDs 19801377 22496122 24357059 29575903 29733200 31251020 32944167 33636221 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.704
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
38
LNCaP cells
Specificity: 0.704
38/46 (82.6%)
6
HAP1 cells
Specificity: 0.111
6/10 (60.0%)
4
PC3 cells
Specificity: 0.074
4/4 (100.0%)
2
DU145 cells
Specificity: 0.037
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.037
2/2 (100.0%)
1
HeLa cells
Specificity: 0.019
1/1 (100.0%)
1
Liver membrane
Specificity: 0.019
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGNGMCSRKQ11KRIFQTLLLL21TVVFGFLYGA31MLYYELQTQL41RKAEAVALKY
51-10051QQHQESLSAQ61LQVVYEHRSR71LEKSLQKERL81EHKKAKEDFL91VYKLEAQETL
101-150101NKGRQDSNSR111YSALNVQHQM121LKSQHEELKK131QHSDLEEEHR141KQGEDFSRTF
151-200151NDHKQKYLQL161QQEKEQELSK171LKETVYNLRE181ENRQLRKAHQ191DIHTQLQDVK
201-250201QQHKNLLSEH211EQLVVTLEDH221KSALAAAQTQ231VAEYKQLKDT241LNRIPSLRKP
251-300251DPAEQQNVTQ261VAHSPQGYNT271AREKPTREVQ281EVSRNNDVWQ291NHEAVPGRAE
301-350301DTKLYAPTHK311EAEFQAPPEP321IQQEVERREP331EEHQVEEEHR341KALEEEEMEQ
351-400351VGQAEHLEEE361HDPSPEEQDR371EWKEQHEQRE381AANLLEGHAR391AEVYPSAKPM
401-450401IKFQSPYEEQ411LEQQRLAVQQ421VEEAQQLREH431QEALHQQRLQ441GHLLRQQEQQ
451-500451QQQVAREMAL461QRQAELEEGR471PQHQEQLRQQ481AHYDAMDNDI491VQGAEDQGIQ
501-550501GEEGAYERDN511QHQDEAEGDP521GNRHEPREQG531PREADPESEA541DRAAVEDINP
551-600551ADDPNNQGED561EFEEAEQVRE571ENLPDENEEQ581KQSNQKQENT591EVEEHLVMAG
601-650601NPDQQEDNVD611EQYQEEAEEE621VQEDLTEEKK631RELEHNAEET641YGENDENTDD
651-696651KNNDGEEQEV661RDDNRPKGRE671EHYEEEEEEE681EDGAAVAEKS691HRRAEM
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
6 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 29575903, 37611173
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
123 S → delinsNTRHILFC 0.001887 INS Splice Region UCEC
305 Y → C 0.002033 SNP Missense Mutation LUSC
327 R → C 0.002288 SNP Missense Mutation STAD
521 G → C 0.002033 SNP Missense Mutation LUSC
527 R → C 0.002288 SNP Missense Mutation STAD
527 R → C 0.002141 SNP Missense Mutation SKCM