Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00461 | GOLIM4 | Golgi integral membrane protein 4 … | Homo sapiens (Human) | 696 aa |
Protein Details: O00461 (GOLIM4)
Protein Information
| Accession | O00461 |
|---|---|
| Protein Names | Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa) |
| Gene Symbol | GOLIM4 |
| Organism | Homo sapiens (Human) |
| Length | 696 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 29575903 29733200 31251020 33636221 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGNGMCSRKQ11KRIFQTLLLL21TVVFGFLYGA31MLYYELQTQL41RKAEAVALKY
51-10051QQHQESLSAQ61LQVVYEHRSR71LEKSLQKERL81EHKKAKEDFL91VYKLEAQETL
101-150101NKGRQDSNSR111YSALNVQHQM121LKSQHEELKK131QHSDLEEEHR141KQGEDFSRTF
151-200151NDHKQKYLQL161QQEKEQELSK171LKETVYNLRE181ENRQLRKAHQ191DIHTQLQDVK
201-250201QQHKNLLSEH211EQLVVTLEDH221KSALAAAQTQ231VAEYKQLKDT241LNRIPSLRKP
251-300251DPAEQQNVTQ261VAHSPQGYNT271AREKPTREVQ281EVSRNNDVWQ291NHEAVPGRAE
301-350301DTKLYAPTHK311EAEFQAPPEP321IQQEVERREP331EEHQVEEEHR341KALEEEEMEQ
351-400351VGQAEHLEEE361HDPSPEEQDR371EWKEQHEQRE381AANLLEGHAR391AEVYPSAKPM
401-450401IKFQSPYEEQ411LEQQRLAVQQ421VEEAQQLREH431QEALHQQRLQ441GHLLRQQEQQ
451-500451QQQVAREMAL461QRQAELEEGR471PQHQEQLRQQ481AHYDAMDNDI491VQGAEDQGIQ
501-550501GEEGAYERDN511QHQDEAEGDP521GNRHEPREQG531PREADPESEA541DRAAVEDINP
551-600551ADDPNNQGED561EFEEAEQVRE571ENLPDENEEQ581KQSNQKQENT591EVEEHLVMAG
601-650601NPDQQEDNVD611EQYQEEAEEE621VQEDLTEEKK631RELEHNAEET641YGENDENTDD
651-696651KNNDGEEQEV661RDDNRPKGRE671EHYEEEEEEE681EDGAAVAEKS691HRRAEM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | SWISSPALM DBPTM CYSMODDB | Golgi integral membrane protein 4 |
HeLa
(37611173)
HeLa
(29575903)
| - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
LNCaP
Specificity: 0.444
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.111
1/1 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
1
EC cell
Specificity: 0.111
1/1 (100.0%)
1
heart
Specificity: 0.111
1/1 (100.0%)
1
HUVECs
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 123 | S → delinsNTRHILFC | 0.001887 | INS | Splice Region | UCEC |
| 305 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 327 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 521 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 527 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 527 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |