Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O00501 | CLDN5 | Claudin-5 (Transmembrane protein deleted in … | Homo sapiens (Human) | 218 aa |
Protein Details: O00501 (CLDN5)
Protein Information
| Accession | O00501 |
|---|---|
| Protein Names | Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF) |
| Gene Symbol | CLDN5 |
| Organism | Homo sapiens (Human) |
| Length | 218 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSAALEILG11LVLCLVGWGG21LILACGLPMW31QVTAFLDHNI41VTAQTTWKGL
51-10051WMSCVVQSTG61HMQCKVYDSV71LALSTEVQAA81RALTVSAVLL91AFVALFVTLA
101-150101GAQCTTCVAP111GPAKARVALT121GGVLYLFCGL131LALVPLCWFA141NIVVREFYDP
151-200151SVPVSQKYEL161GAALYIGWAA171TALLMVGGCL181LCCGAWVCTG191RPDLSFPVKY
201-218201SAPRRPTATG211DYDKKNYV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 14 | - | - | - |
Deep-Palm: 0.98
|
|
| 25 | Claudin | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.88
|
|
| 54 | - | - | - |
Deep-Palm: 0.05
|
|
| 64 | - | - | - |
Deep-Palm: 0.14
|
|
| 104 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.95
|
|
| 107 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
|
| 128 | - | - | - |
Deep-Palm: 0.96
|
|
| 137 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.93
|
|
| 179 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.89
|
|
| 182 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.91
|
|
| 183 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.92
|
|
| 188 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.86
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 47 | W → C | 0.010870 | SNP | Missense Mutation | ACC |
| 54 | C → R | 0.001014 | SNP | Missense Mutation | BRCA |
| 107 | C → Sfs*70 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 107 | C → Y | 0.002747 | SNP | Missense Mutation | LIHC |