Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O09173 | Hgd | Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate … | Mus musculus (Mouse) | 445 aa |
Protein Details: O09173 (Hgd)
Protein Information
| Accession | O09173 |
|---|---|
| Protein Names | Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase) |
| Gene Symbol | Hgd |
| Organism | Mus musculus (Mouse) |
| Length | 445 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 34884899 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAELKYISGF11GNECASEDPR21CPGSLPKGQN31NPQVCPYNLY41AEQLSGSAFT
51-10051CPRNTNKRSW61LYRILPSVSH71KPFESIDQGH81VTHNWDEVGP91DPNQLRWKPF
101-150101EIPKASEKKV111DFVSGLYTLC121GAGDIKSNNG131LAVHIFLCNS141SMENRCFYNS
151-200151DGDFLIVPQK161GKLLIYTEFG171KMSLQPNEIC181VIQRGMRFSV191DVFEETRGYI
201-250201LEVYGVHFEL211PDLGPIGANG221LANPRDFLIP231VAWYEDRRVP241GGYTVINKFQ
251-300251GKLFACKQDV261SPFNVVAWHG271NYTPYKYNLE281NFMVINAVAF291DHADPSIFTV
301-350301LTAKSLRPGV311AIADFVIFPP321RWGVADKTFR331PPYYHRNCMS341EFMGLIKGHY
351-400351EAKQGGFLPG361GGSLHSAMTP371HGPDADCFEK381ASKAKLEPER391IADGTMAFMF
401-445401ESSLSLAVTK411WGLKTCSCLD421ENYYKCWEPL431RSHFTPNSRS441PTEPK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 14 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1,2-dioxygenase, N-terminal domain RmlC-like cupin domain superfamily Homogentisate 1 2-dioxygenase N-terminal |
Liver
(28526873)
| - |
GPS-Palm: 0.85
Deep-Palm: 0.50
|
| 21 | Homogentisate 1,2-dioxygenase, N-terminal domain RmlC-like cupin domain superfamily Homogentisate 1,2-dioxygenase | - | - |
Deep-Palm: 0.17
|
|
| 35 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1,2-dioxygenase, N-terminal domain RmlC-like cupin domain superfamily Homogentisate 1 2-dioxygenase N-terminal Homogentisate 1,2-dioxygenase |
Liver
(28526873)
| - |
GPS-Palm: 0.66
Deep-Palm: 0.53
|
| 51 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1 2-dioxygenase N-terminal Homogentisate 1,2-dioxygenase |
Liver
(28526873)
| - |
GPS-Palm: 0.92
Deep-Palm: 0.79
|
| 120 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1 2-dioxygenase N-terminal |
Liver
(28526873)
| - |
GPS-Palm: 0.81
Deep-Palm: 0.95
|
| 138 | - | - | - |
Deep-Palm: 0.16
|
|
| 146 | - | - | - |
Deep-Palm: 0.15
|
|
| 180 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1 2-dioxygenase N-terminal |
Liver
(28526873)
|
Liver
(34884899)
|
GPS-Palm: 0.88
Deep-Palm: 0.81
|
| 256 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.42
|
|
| 338 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1 2-dioxygenase C-terminal |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.76
Deep-Palm: 0.55
|
| 377 | - | - | - |
Deep-Palm: 0.95
|
|
| 416 | SWISSPALM DBPTM CYSMODDB | Homogentisate 1 2-dioxygenase C-terminal |
Liver
(28526873)
| - |
GPS-Palm: 0.93
Deep-Palm: 0.86
|
| 418 | Homogentisate 1 2-dioxygenase C-terminal |
Liver
(28526873)
| - |
GPS-Palm: 0.66
Deep-Palm: 0.81
|
|
| 426 | - | - | - |
Deep-Palm: 0.21
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
6
Liver
Specificity: 0.462
6/6 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.857
6
Brain tissue (Mass)
Specificity: 0.462
6/56 (10.7%)
1
Liver tissue (Mass)
Specificity: 0.077
1/8 (12.5%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.