Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O14734 | ACOT8; ACTEIII; PTE1 | Acyl-coenzyme A thioesterase 8 (Acyl-CoA … | Homo sapiens (Human) | 319 aa |
Protein Details: O14734 (ACOT8)
Protein Information
| Accession | O14734 |
|---|---|
| Protein Names | Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE) |
| Gene Symbol | ACOT8; ACTEIII; PTE1 |
| Organism | Homo sapiens (Human) |
| Length | 319 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.912
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
31
LNCaP cells
Specificity: 0.912
31/46 (67.4%)
3
T cells
Specificity: 0.088
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSSPQAPEDG11QGCGDRGDPP21GDLRSVLVTT31VLNLEPLDED41LFRGRHYWVP
51-10051AKRLFGGQIV61GQALVAAAKS71VSEDVHVHSL81HCYFVRAGDP91KLPVLYQVER
101-150101TRTGSSFSVR111SVKAVQHGKP121IFICQASFQQ131AQPSPMQHQF141SMPTVPPPEE
151-200151LLDCETLIDQ161YLRDPNLQKR171YPLALNRIAA181QEVPIEIKPV191NPSPLSQLQR
201-250201MEPKQMFWVR211ARGYIGEGDM221KMHCCVAAYI231SDYAFLGTAL241LPHQWQHKVH
251-300251FMVSLDHSMW261FHAPFRADHW271MLYECESPWA281GGSRGLVHGR291LWRQDGVLAV
301-319301TCAQEGVIRV311KPQVSESKL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 124 | Prediction (Low) | - | - |
| 275 | Prediction (Low) | - | - |
| 302 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 110 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 224 | C → C | 0.001887 | SNP | Silent | UCEC |
| 273 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |