Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O14734 | ACOT8 | Acyl-coenzyme A thioesterase 8 (Acyl-CoA … | Homo sapiens (Human) | 319 aa |
Protein Details: O14734 (ACOT8)
Protein Information
| Accession | O14734 |
|---|---|
| Protein Names | Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE) |
| Gene Symbol | ACOT8 |
| Organism | Homo sapiens (Human) |
| Length | 319 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSPQAPEDG11QGCGDRGDPP21GDLRSVLVTT31VLNLEPLDED41LFRGRHYWVP
51-10051AKRLFGGQIV61GQALVAAAKS71VSEDVHVHSL81HCYFVRAGDP91KLPVLYQVER
101-150101TRTGSSFSVR111SVKAVQHGKP121IFICQASFQQ131AQPSPMQHQF141SMPTVPPPEE
151-200151LLDCETLIDQ161YLRDPNLQKR171YPLALNRIAA181QEVPIEIKPV191NPSPLSQLQR
201-250201MEPKQMFWVR211ARGYIGEGDM221KMHCCVAAYI231SDYAFLGTAL241LPHQWQHKVH
251-300251FMVSLDHSMW261FHAPFRADHW271MLYECESPWA281GGSRGLVHGR291LWRQDGVLAV
301-319301TCAQEGVIRV311KPQVSESKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | - | - | - |
Deep-Palm: 0.24
|
|
| 82 | - | - | - |
Deep-Palm: 0.90
|
|
| 124 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.27
|
|
| 154 | - | - | - |
Deep-Palm: 0.66
|
|
| 224 | - | - | - |
Deep-Palm: 0.43
|
|
| 225 | - | - | - |
Deep-Palm: 0.23
|
|
| 275 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.22
|
|
| 302 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
LNCaP
Specificity: 0.571
4/4 (100.0%)
3
Primary T cell
Specificity: 0.429
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 110 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 224 | C → C | 0.001887 | SNP | Silent | UCEC |
| 273 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |