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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O14744 PRMT5 Protein arginine N-methyltransferase 5 (PRMT5) … Homo sapiens (Human) 637 aa

Protein Details: O14744 (PRMT5)

Protein Information
AccessionO14744
Protein NamesProtein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene SymbolPRMT5
OrganismHomo sapiens (Human)
Length637 aa
IsoformsNo isoforms
Related PMIDs 29733200
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAMAVGGAG11GSRVSSGRDL21NCVPEIADTL31GAVAKQGFDF41LCMPVFHPRF
51-10051KREFIQEPAK61NRPGPQTRSD71LLLSGRDWNT81LIVGKLSPWI91RPDSKVEKIR
101-150101RNSEAAMLQE111LNFGAYLGLP121AFLLPLNQED131NTNLARVLTN141HIHTGHHSSM
151-200151FWMRVPLVAP161EDLRDDIIEN171APTTHTEEYS181GEEKTWMWWH191NFRTLCDYSK
201-250201RIAVALEIGA211DLPSNHVIDR221WLGEPIKAAI231LPTSIFLTNK241KGFPVLSKMH
251-300251QRLIFRLLKL261EVQFIITGTN271HHSEKEFCSY281LQYLEYLSQN291RPPPNAYELF
301-350301AKGYEDYLQS311PLQPLMDNLE321SQTYEVFEKD331PIKYSQYQQA341IYKCLLDRVP
351-400351EEEKDTNVQV361LMVLGAGRGP371LVNASLRAAK381QADRRIKLYA391VEKNPNAVVT
401-450401LENWQFEEWG411SQVTVVSSDM421REWVAPEKAD431IIVSELLGSF441ADNELSPECL
451-500451DGAQHFLKDD461GVSIPGEYTS471FLAPISSSKL481YNEVRACREK491DRDPEAQFEM
501-550501PYVVRLHNFH511QLSAPQPCFT521FSHPNRDPMI531DNNRYCTLEF541PVEVNTVLHG
551-600551FAGYFETVLY561QDITLSIRPE571THSPGMFSWF581PILFPIKQPI591TVREGQTICV
601-637601RFWRCSNSKK611VWYEWAVTAP621VCSAIHNPTG631RSYTIGL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
22 SWISSPALM DBPTM CYSMODDB -
SW480 cell line (26865113)
-
GPS-Palm: 0.74
Deep-Palm: 0.96
42 - - -
GPS-Palm: 0.77
Deep-Palm: 0.95
196 - - -
Deep-Palm: 0.21
278 - - -
Deep-Palm: 0.11
344 - - -
GPS-Palm: 0.68
Deep-Palm: 0.84
449 - -
Unknown (32651440)
Deep-Palm: 0.96
487 - - -
Deep-Palm: 0.78
518 - - -
Deep-Palm: 0.06
536 - - -
Deep-Palm: 0.06
599 - - -
GPS-Palm: 0.83
Deep-Palm: 0.34
605 - - -
GPS-Palm: 0.66
Deep-Palm: 0.18
622 - - -
Deep-Palm: 0.50
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
HAP1 cell
Specificity: 0.500
1/1 (100.0%)
1
293T cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
49 R → C 0.001764 SNP Missense Mutation LUAD
64 G → C 0.001764 SNP Missense Mutation LUAD
100 R → C 0.002141 SNP Missense Mutation SKCM
534 R → C 0.002506 SNP Missense Mutation COAD