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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O14817 TSPAN4; NAG2; TM4SF7 Tetraspanin-4 (Tspan-4) (Novel antigen 2) … Homo sapiens (Human) 238 aa

Protein Details: O14817 (TSPAN4)

Protein Information
Accession O14817
Protein Names Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)
Gene Symbol TSPAN4; NAG2; TM4SF7
Organism Homo sapiens (Human)
Length 238 aa
Isoforms No isoforms
Related PMIDs 19801377 31251020
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
2
LNCaP cells
Specificity: 0.667
2/46 (4.3%)
1
DU145 cells
Specificity: 0.333
1/2 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MARACLQAVK11YLMFAFNLLF21WLGGCGVLGV31GIWLAATQGS41FATLSSSFPS
51-10051LSAANLLIIT61GAFVMAIGFV71GCLGAIKENK81CLLLTFFLLL91LLVFLLEATI
101-150101AILFFAYTDK111IDRYAQQDLK121KGLHLYGTQG131NVGLTNAWSI141IQTDFRCCGV
151-200151SNYTDWFEVY161NATRVPDSCC171LEFSESCGLH181APGTWWKAPC191YETVKVWLQE
201-238201NLLAVGIFGL211CTALVQILGL221TFAMTMYCQV231VKADTYCA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
5 Prediction (High) - -
72 Prediction (High) - -
81 Prediction (Low) - -
147 Prediction (Low) - -
148 Prediction (Medium) - -
211 Prediction (Medium) - -
228 CYSMODDB SWISSPALM DBPTM Prediction (Low) - -
237 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
46 S → C 0.003460 SNP Missense Mutation CESC
228 C → Y 0.002288 SNP Missense Mutation STAD
81* C → ? 0.005618 SNP Nonsense Mutation PAAD