Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15015 | ZNF646 | Zinc finger protein 646 | Homo sapiens (Human) | 1832 aa |
Protein Details: O15015 (ZNF646)
Protein Information
| Accession | O15015 |
|---|---|
| Protein Names | Zinc finger protein 646 |
| Gene Symbol | ZNF646 |
| Organism | Homo sapiens (Human) |
| Length | 1832 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEDTPPSLSC11SDCQRHFPSL21PELSRHRELL31HPSPNQDSEE41ADSIPRPYRC
51-10051QQCGRGYRHP61GSLVNHRRTH71ETGLFPCTTC81GKDFSNPMAL91KSHMRTHAPE
101-150101GRRRHRPPRP111KEATPHLQGE121TVSTDSWGQR131LGSSEGWENQ141TKHTEETPDC
151-200151ESVPDPRAAS161GTWEDLPTRQ171REGLASHPGP181EDGADGWGPS191TNSARAPPLP
201-250201IPASSLLSNL211EQYLAESVVN221FTGGQEPTQS231PPAEEERRYK241CSQCGKTYKH
251-300251AGSLTNHRQS261HTLGIYPCAI271CFKEFSNLMA281LKNHSRLHAQ291YRPYHCPHCP
301-350301RVFRLPRELL311EHQQSHEGER321QEPRWEEKGM331PTTNGHTDES341SQDQLPSAQM
351-400351LNGSAELSTS361GELEDSGLEE371YRPFRCGDCG381RTYRHAGSLI391NHRKSHQTGV
401-450401YPCSLCSKQL411FNAAALKNHV421RAHHRPRQGV431GENGQPSVPP441APLLLAETTH
451-500451KEEEDPTTTL461DHRPYKCSEC471GRAYRHRGSL481VNHRHSHRTG491EYQCSLCPRK
501-550501YPNLMALRNH511VRVHCKAARR521SADIGAEGAP531SHLKVELPPD541PVEAEAAPHT
551-600551DQDHVCKHEE561EATDITPAAD571KTAAHICSIC581GLLFEDAESL591ERHGLTHGAG
601-650601EKENSRTETT611MSPPRAFACR621DCGKSYRHSG631SLINHRQTHQ641TGDFSCGACA
651-700651KHFHTMAAMK661NHLRRHSRRR671SRRHRKRAGG681ASGGREAKLL691AAESWTRELE
701-750701DNEGLESPQD711PSGESPHGAE721GNLESDGDCL731QAESEGDKCG741LERDETHFQG
751-800751DKESGGTGEG761LERKDASLLD771NLDIPGEEGG781GTHFCDSLTG791VDEDQKPATG
801-850801QPNSSSHSAN811AVTGWQAGAA821HTCSDCGHSF831PHATGLLSHR841PCHPPGIYQC
851-900851SLCPKEFDSL861PALRSHFQNH871RPGEATSAQP881FLCCLCGMIF891PGRAGYRLHR
901-950901RQAHSSSGMT911EGSEEEGEEE921GVAEAAPARS931PPLQLSEAEL941LNQLQREVEA
951-1000951LDSAGYGHIC961GCCGQTYDDL971GSLERHHQSQ981SSGTTADKAP991SPLGVAGDAM
1001-10501001EMVVDSVLED1011IVNSVSGEGG1021DAKSQEGAGT1031PLGDSLCIQG1041GESLLEAQPR
1051-11001051PFRCNQCGKT1061YRHGGSLVNH1071RKIHQTGDFL1081CPVCSRCYPN1091LAAYRNHLRN
1101-11501101HPRCKGSEPQ1111VGPIPEAAGS1121SELQVGPIPE1131GGSNKPQHMA1141EEGPGQAEVE
1151-12001151KLQEELKVEP1161LEEVARVKEE1171VWEETTVKGE1181EIEPRLETAE1191KGCQTEASSE
1201-12501201RPFSCEVCGR1211SYKHAGSLIN1221HRQSHQTGHF1231GCQACSKGFS1241NLMSLKNHRR
1251-13001251IHADPRRFRC1261SECGKAFRLR1271KQLASHQRVH1281MERRGGGGTR1291KATREDRPFR
1301-13501301CGQCGRTYRH1311AGSLLNHRRS1321HETGQYSCPT1331CPKTYSNRMA1341LKDHQRLHSE
1351-14001351NRRRRAGRSR1361RTAVRCALCG1371RSFPGRGSLE1381RHLREHEETE1391REPANGQGGL
1401-14501401DGTAASEANL1411TGSQGLETQL1421GGAEPVPHLE1431DGVPRPGERS1441QSPIRAASSE
1451-15001451APEPLSWGAG1461KAGGWPVGGG1471LGNHSGGWVP1481QFLTRSEEPE1491DSVHRSPCHA
1501-15501501GDCQLNGPTL1511SHMDSWDNRD1521NSSQLQPGSH1531SSCSQCGKTY1541CQSGSLLNHN
1551-16001551TNKTDRHYCL1561LCSKEFLNPV1571ATKSHSHNHI1581DAQTFACPDC1591GKAFESHQEL
1601-16501601ASHLQAHARG1611HSQVPAQMEE1621ARDPKAGTGE1631DQVVLPGQGK1641AQEAPSETPR
1651-17001651GPGESVERAR1661GGQAVTSMAA1671EDKERPFRCT1681QCGRSYRHAG1691SLLNHQKAHT
1701-17501701TGLYPCSLCP1711KLLPNLLSLK1721NHSRTHTDPK1731RHCCSICGKA1741FRTAARLEGH
1751-18001751GRVHAPREGP1761FTCPHCPRHF1771RRRISFVQHQ1781QQHQEEWTVA1791GSGAPVAPVT
1801-18321801GRGDLPLPPP1811PTPTTPLLDP1821SPQWPADLSF1831SL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | Zinc finger C2H2-type | - | - |
Deep-Palm: 0.05
|
|
| 13 | Zinc finger C2H2-type | - | - |
Deep-Palm: 0.14
|
|
| 50 | - | - | - |
Deep-Palm: 0.27
|
|
| 53 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.20
|
|
| 77 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.59
|
|
| 80 | - | - | - |
Deep-Palm: 0.15
|
|
| 150 | - | - | - |
Deep-Palm: 0.31
|
|
| 241 | - | - | - |
Deep-Palm: 0.37
|
|
| 244 | - | - | - |
Deep-Palm: 0.22
|
|
| 268 | - | - | - |
Deep-Palm: 0.14
|
|
| 271 | - | - | - |
Deep-Palm: 0.09
|
|
| 296 | - | - | - |
Deep-Palm: 0.42
|
|
| 299 | - | - | - |
Deep-Palm: 0.19
|
|
| 376 | - | - | - |
Deep-Palm: 0.78
|
|
| 379 | - | - | - |
Deep-Palm: 0.56
|
|
| 403 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.62
|
|
| 406 | - | - | - |
Deep-Palm: 0.30
|
|
| 467 | - | - | - |
Deep-Palm: 0.31
|
|
| 470 | - | - | - |
Deep-Palm: 0.12
|
|
| 494 | - | - | - |
Deep-Palm: 0.26
|
|
| 497 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.13
|
|
| 515 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.81
|
|
| 556 | - | - | - |
Deep-Palm: 0.13
|
|
| 577 | - | - | - |
Deep-Palm: 0.61
|
|
| 580 | - | - | - |
Deep-Palm: 0.47
|
|
| 619 | - | - | - |
Deep-Palm: 0.54
|
|
| 622 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.28
|
|
| 646 | - | - | - |
Deep-Palm: 0.06
|
|
| 649 | - | - | - |
Deep-Palm: 0.04
|
|
| 729 | - | - | - |
Deep-Palm: 0.87
|
|
| 739 | - | - | - |
Deep-Palm: 0.77
|
|
| 785 | - | - | - |
Deep-Palm: 0.74
|
|
| 823 | - | - | - |
Deep-Palm: 0.27
|
|
| 826 | - | - | - |
Deep-Palm: 0.21
|
|
| 842 | - | - | - |
Deep-Palm: 0.21
|
|
| 850 | - | - | - |
Deep-Palm: 0.59
|
|
| 853 | - | - | - |
Deep-Palm: 0.19
|
|
| 883 | - | - | - |
Deep-Palm: 0.52
|
|
| 884 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.40
|
|
| 886 | - | - | - |
Deep-Palm: 0.51
|
|
| 960 | - | - | - |
Deep-Palm: 0.47
|
|
| 962 | - | - | - |
Deep-Palm: 0.20
|
|
| 963 | - | - | - |
Deep-Palm: 0.15
|
|
| 1037 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.98
|
|
| 1054 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.84
|
| 1057 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.49
|
| 1081 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.15
|
|
| 1084 | - | - | - |
Deep-Palm: 0.08
|
|
| 1087 | - | - | - |
Deep-Palm: 0.06
|
|
| 1104 | - | - | - |
Deep-Palm: 0.69
|
|
| 1193 | - | - | - |
Deep-Palm: 0.80
|
|
| 1205 | - | - | - |
Deep-Palm: 0.43
|
|
| 1208 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.25
|
|
| 1232 | - | - | - |
Deep-Palm: 0.07
|
|
| 1235 | - | - | - |
Deep-Palm: 0.06
|
|
| 1260 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.84
|
|
| 1263 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.82
|
|
| 1301 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.81
|
|
| 1304 | - | - | - |
Deep-Palm: 0.60
|
|
| 1328 | - | - | - |
Deep-Palm: 0.19
|
|
| 1331 | - | - | - |
Deep-Palm: 0.07
|
|
| 1366 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.95
|
|
| 1369 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.87
|
|
| 1498 | - | - | - |
Deep-Palm: 0.40
|
|
| 1503 | - | - | - |
Deep-Palm: 0.08
|
|
| 1533 | - | - | - |
Deep-Palm: 0.08
|
|
| 1536 | - | - | - |
Deep-Palm: 0.05
|
|
| 1541 | - | - | - |
Deep-Palm: 0.05
|
|
| 1559 | - | - | - |
Deep-Palm: 0.29
|
|
| 1562 | - | - | - |
Deep-Palm: 0.05
|
|
| 1587 | - | - | - |
Deep-Palm: 0.09
|
|
| 1590 | - | - | - |
Deep-Palm: 0.05
|
|
| 1679 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.71
|
|
| 1682 | - | - | - |
Deep-Palm: 0.52
|
|
| 1706 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.84
|
|
| 1709 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.77
|
|
| 1733 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.67
|
|
| 1734 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.67
|
|
| 1737 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.52
|
|
| 1763 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.18
|
|
| 1766 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 57 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 244 | C → Y | 0.001969 | SNP | Missense Mutation | HNSC |
| 244 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 301 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 580 | C → Y | 0.005618 | SNP | Missense Mutation | PAAD |
| 649 | C → Lfs*11 | 0.002506 | DEL | Frame Shift Del | COAD |
| 776 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 785 | C → C | 0.001887 | SNP | Silent | UCEC |
| 850 | C → Y | 0.002020 | SNP | Missense Mutation | PRAD |
| 907 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 997 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1016 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1037 | C → C | 0.002427 | SNP | Silent | BLCA |
| 1054 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1071 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1081 | C → G | 0.001969 | SNP | Missense Mutation | HNSC |
| 1084 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1087 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1119 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1259 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1300 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1328 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1365 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1366 | C → Lfs*22 | 0.002506 | INS | Frame Shift Ins | COAD |
| 1559 | C → W | 0.002294 | SNP | Missense Mutation | OV |
| 1684 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 1687 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1709 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 1718 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 497* | C → ? | 0.002506 | SNP | Nonsense Mutation | COAD |
| 470* | C → ? | 0.007299 | SNP | Nonsense Mutation | READ |
| 962* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |